About Spermatogenesis-associated protein 2
Spermatogenesis-associated protein 2 (SPATA2) is a protein
from Homo sapiens identified by UniProt accession
Q9UM82, 520 residues long.
MolForge cross-references it against 0 known binders and
134 disease associations.
Target properties
| Protein name | Spermatogenesis-associated protein 2 |
|---|
| UniProt accession | Q9UM82 |
|---|
| Gene | SPATA2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 520 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (134)
Diseases linked to this target (Open Targets).
- systemic lupus erythematosus · score 0.17
- eosinophil count · score 0.16
- psoriasis · score 0.13
- age at menopause · score 0.11
- type 2 diabetes mellitus · score 0.10
- lymphocyte percentage of leukocytes · score 0.09
- azoospermia · score 0.09
- neoplasm · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- non-small cell lung carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UM82-F1 | alphafold | PREDICTED | 68.39 | — |
Amino-acid sequence (520 residues)
MGKPSSMDTK FKDDLFRKYV QFHESKVDTT TSRQRPGSDE CLRVAASTLL SLHKVDPFYR FRLIQFYEVV ESSLRSLSSS SLRALHGAFS MLETVGINLF LYPWKKEFRS IKTYTGPFVY YVKSTLLEED IRAILSCMGY TPELGTAYKL RELVETLQVK MVSFELFLAK VECEQMLEIH SQVKDKGYSE LDIVSERKSS AEDVRGCSDA LRRRAEGREH LTASMSRVAL QKSASERAAK DYYKPRVTKP SRSVDAYDSY WESRKPPLKA SLSLRKEPVA TDVGDDLKDE IIRPSPSLLT MASSPHGSPD VLPPASPSNG PALLRGTYFS TQDDVDLYTD SEPRATYRRQ DALRPDVWLL RNDAHSLYHK RSPPAKESAL SKCQSCGLSC SSSLCQRCDS LLTCPPASKP SAFPSKASTH DSLAHGASLR EKYPGQTQGL DRLPHLHSKS KPSTTPTSRC GFCNRPGATN TCTQCSKVSC DACLSAYHYD PCYKKSELHK FMPNNQLNYK STQLSHLVYR
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