ATP-dependent RNA helicase DDX19B (DDX19B)

About ATP-dependent RNA helicase DDX19B

ATP-dependent RNA helicase DDX19B (DDX19B) is a protein from Homo sapiens identified by UniProt accession Q9UMR2, 479 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.

Target properties

Protein name	ATP-dependent RNA helicase DDX19B
UniProt accession	Q9UMR2
Gene	DDX19B
Organism	Homo sapiens
Length	479 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (97)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.21
haptoglobin measurement · score 0.17
body mass index · score 0.14
body height · score 0.14
amino acid measurement · score 0.09
azoospermia · score 0.08
urate measurement · score 0.08
male infertility with teratozoospermia due to single gene mutation · score 0.07
protein measurement · score 0.06
blood metabolite measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UMR2-F1	alphafold	PREDICTED	81.53	—

Amino-acid sequence (479 residues)

MATDSWALAV DEQEAAAESL SNLHLKEEKI KPDTNGAVVK TNANAEKTDE EEKEDRAAQS LLNKLIRSNL VDNTNQVEVL QRDPNSPLYS VKSFEELRLK PQLLQGVYAM GFNRPSKIQE NALPLMLAEP PQNLIAQSQS GTGKTAAFVL AMLSQVEPAN KYPQCLCLSP TYELALQTGK VIEQMGKFYP ELKLAYAVRG NKLERGQKIS EQIVIGTPGT VLDWCSKLKF IDPKKIKVFV LDEADVMIAT QGHQDQSIRI QRMLPRNCQM LLFSATFEDS VWKFAQKVVP DPNVIKLKRE EETLDTIKQY YVLCSSRDEK FQALCNLYGA ITIAQAMIFC HTRKTASWLA AELSKEGHQV ALLSGEMMVE QRAAVIERFR EGKEKVLVTT NVCARGIDVE QVSVVINFDL PVDKDGNPDN ETYLHRIGRT GRFGKRGLAV NMVDSKHSMN ILNRIQEHFN KKIERLDTDD LDEIEKIAN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards