About Protein PHTF1
Protein PHTF1 (PHTF1) is a protein
from Homo sapiens identified by UniProt accession
Q9UMS5, 762 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | Protein PHTF1 |
|---|
| UniProt accession | Q9UMS5 |
|---|
| Gene | PHTF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 762 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (117)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- type 1 diabetes mellitus · score 0.27
- metabolic disease · score 0.26
- complication · score 0.24
- parental longevity · score 0.24
- connective tissue disease · score 0.23
- endocrine system disease · score 0.22
- thyroid peroxidase antibody measurement · score 0.20
- Crohn's disease · score 0.20
- rheumatoid arthritis · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UMS5-F1 | alphafold | PREDICTED | 61.54 | — |
Amino-acid sequence (762 residues)
MASNERDAIS WYQKKIGAYD QQIWEKSIEQ TQIKGLKNKP KKMGHIKPDL IDVDLIRGST FAKAKPEIPW TSLTRKGLVR VVFFPLFSNW WIQVTSLRIF VWLLLLYFMQ VIAIVLYLMM PIVNISEVLG PLCLMLLMGT VHCQIVSTQI TRPSGNNGNR RRRKLRKTVN GDGSRENGNN SSDKVRGIET LESVPIIGGF WETIFGNRIK RVKLISNKGT ETDNDPSCVH PIIKRRQCRP EIRMWQTREK AKFSDGEKCR REAFRRLGNG VSDDLSSEED GEARTQMILL RRSVEGASSD NGCEVKNRKS ILSRHLNSQV KKTTTRWCHI VRDSDSLAES EFESAAFSQG SRSGVSGGSR SLNMSRRDSE STRHDSETED MLWDDLLHGP ECRSSVTSDS EGAHVNTLHS GTKRDPKEDV FQQNHLFWLQ NSSPSSDRVS AIIWEGNECK KMDMSVLEIS GIIMSRVNAY QQGVGYQMLG NVVTIGLAFF PFLHRLFREK SLDQLKSISA EEILTLFCGA PPVTPIIVLS IINFFERLCL TWMFFFMMCV AERTYKQRFL FAKLFSHITS ARKARKYEIP HFRLKKVENI KIWLSLRSYL KRRGPQRSVD VVVSSVFLLT LSIAFICCAQ VLQGHKTFLN DAYNWEFLIW ETALLLFLLR LASLGSETNK KYSNVSILLT EQINLYLKME KKPNKKEQLT LVNNVLKLST KLLKELDTPF RLYGLTMNPL IYNITRVVIL SAVSGVISDL LGFNIRLWKI KS
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