Ornithine decarboxylase antizyme 3 (OAZ3)

About Ornithine decarboxylase antizyme 3

Ornithine decarboxylase antizyme 3 (OAZ3) is a protein from Homo sapiens identified by UniProt accession Q9UMX2, 235 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.

Target properties

Protein name	Ornithine decarboxylase antizyme 3
UniProt accession	Q9UMX2
Gene	OAZ3
Organism	Homo sapiens
Length	235 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (106)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
hemoglobin measurement · score 0.24
hematocrit · score 0.11
antisocial behaviour measurement · score 0.11
substance abuse · score 0.11
attention deficit hyperactivity disorder · score 0.11
azoospermia · score 0.10
serum gamma-glutamyl transferase measurement · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.09
erythrocyte count · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UMX2-F1	alphafold	PREDICTED	65.07	—

Amino-acid sequence (235 residues)

MPCKRCRPSV YSLSYIKRGK TRNYLYPIWS PYAYYLYCYK YRITLREKML PRCYKSITYK EEEDLTLQPR SCLQCSESLV GLQEGKSTEQ GNHDQLKELY SAGNLTVLAT DPLLHQDPVQ LDFHFRLTSQ TSAHWHGLLC DRRLFLDIPY QALDQGNRES LTATLEYVEE KTNVDSVFVN FQNDRNDRGA LLRAFSYMGF EVVRPDHPAL PPLDNVIFMV YPLERDVGHL PSEPP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards