About Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (DAPP1) is a protein
from Homo sapiens identified by UniProt accession
Q9UN19, 280 residues long.
MolForge cross-references it against 0 known binders and
160 disease associations.
Target properties
| Protein name | Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide |
|---|
| UniProt accession | Q9UN19 |
|---|
| Gene | DAPP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 280 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (160)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.29
- mean platelet volume · score 0.25
- lymphocyte count · score 0.20
- endometrial cancer · score 0.18
- platelet count · score 0.17
- lean body mass · score 0.15
- appendicular lean mass · score 0.13
- mean reticulocyte volume · score 0.12
- age at menopause · score 0.11
- inflammatory bowel disease · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UN19-F1 | alphafold | PREDICTED | 85.08 | — |
Amino-acid sequence (280 residues)
MGRAELLEGK MSTQDPSDLW SRSDGEAELL QDLGWYHGNL TRHAAEALLL SNGCDGSYLL RDSNETTGLY SLSVRAKDSV KHFHVEYTGY SFKFGFNEFS SLKDFVKHFA NQPLIGSETG TLMVLKHPYP RKVEEPSIYE SVRVHTAMQT GRTEDDLVPT APSLGTKEGY LTKQGGLVKT WKTRWFTLHR NELKYFKDQM SPEPIRILDL TECSAVQFDY SQERVNCFCL VFPFRTFYLC AKTGVEADEW IKILRWKLSQ IRKQLNQGEG TIRSRSFIFK
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