Vacuolar protein sorting-associated protein 4A (VPS4A)

About Vacuolar protein sorting-associated protein 4A

Vacuolar protein sorting-associated protein 4A (VPS4A) is a protein from Homo sapiens identified by UniProt accession Q9UN37, 437 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	Vacuolar protein sorting-associated protein 4A
UniProt accession	Q9UN37
Gene	VPS4A
Organism	Homo sapiens
Length	437 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

cerebellar hypoplasia-intellectual disability-congenital microcephaly-dystonia-anemia-growth retardation syndrome · score 0.71
viral disease · score 0.47
HIV infection · score 0.46
genetic disorder · score 0.18
breast carcinoma · score 0.15
body fat percentage · score 0.09
cancer · score 0.09
axial length measurement · score 0.07
IGF-1 measurement · score 0.06
infection · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UN37-F1	alphafold	PREDICTED	85.69	—

Amino-acid sequence (437 residues)

MTTSTLQKAI DLVTKATEED KAKNYEEALR LYQHAVEYFL HAIKYEAHSD KAKESIRAKC VQYLDRAEKL KDYLRSKEKH GKKPVKENQS EGKGSDSDSE GDNPEKKKLQ EQLMGAVVME KPNIRWNDVA GLEGAKEALK EAVILPIKFP HLFTGKRTPW RGILLFGPPG TGKSYLAKAV ATEANNSTFF SVSSSDLMSK WLGESEKLVK NLFELARQHK PSIIFIDEVD SLCGSRNENE SEAARRIKTE FLVQMQGVGN NNDGTLVLGA TNIPWVLDSA IRRRFEKRIY IPLPEEAARA QMFRLHLGST PHNLTDANIH ELARKTEGYS GADISIIVRD SLMQPVRKVQ SATHFKKVCG PSRTNPSMMI DDLLTPCSPG DPGAMEMTWM DVPGDKLLEP VVCMSDMLRS LATTRPTVNA DDLLKVKKFS EDFGQES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards