About Protocadherin alpha-12
Protocadherin alpha-12 (PCDHA12) is a protein
from Homo sapiens identified by UniProt accession
Q9UN75, 941 residues long.
MolForge cross-references it against 0 known binders and
12 disease associations.
Target properties
| Protein name | Protocadherin alpha-12 |
|---|
| UniProt accession | Q9UN75 |
|---|
| Gene | PCDHA12 |
|---|
| Organism | Homo sapiens |
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| Length | 941 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (12)
Diseases linked to this target (Open Targets).
- Hirschsprung disease · score 0.11
- granulocyte count · score 0.09
- sum of neutrophil and eosinophil counts · score 0.09
- vital capacity · score 0.07
- myeloid white cell count · score 0.05
- neutrophil count · score 0.05
- Abnormality of refraction · score 0.05
- sum of basophil and neutrophil counts · score 0.05
- metastatic neoplasm · score 0.00
- neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UN75-F1 | alphafold | PREDICTED | 74.23 | — |
Amino-acid sequence (941 residues)
MVIIGPRGPG SQRLLLSLLL LAAWEVGSGQ LHYSVYEEAK HGTFVGRIAQ DLGLELAELV PRLFRVASKR HGDLLEVNLQ NGILFVNSRI DREKLCGRSA ECSIHLEVIV DRPLQVFHVD VEVKDINDNP PVFREREQKV PVSESAPLDS HFPLEGASDA DIGVNSLLTY ALSLNENFEL KIKTKKDKSI LPELVLRKLL DREQTPKLNL LLMVIDGGKP ELTGSVQIQI TVLDVNDNGP AFDKPSYKVV LSENVQNDTR VIQLNASDPD EGLNGEISYG IKMILPVSEK CMFSINPDTG EIRIYGELDF EENNAYEIQV NAIDKGIPSM AGHSMVLVEV LDVNDNVPEV MVTSLSLPVQ EDAQVGTVIA LISVSDRDSG ANGQVICSLT PHVPFKLVST YKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATAR VSVEVADVND NAPAFAQPEY TVFVKENNPP GCHIFTVSAW DADAQKNALV SYSLVERRVG EHALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT LQVFVLDEND NAPALLATPA GSAGGAVSEL VPRSVGAGHV VAKVRAVDAD SGYNAWLSYE LQPAAVGAHI PFHVGLYTGE ISTTRILDEA DAPRHRLLVL VKDHGEPALT STATVLVSLV ENGQAPKTSS RASVGAVDPE AALVDINVYL IIAICAVSSL LVLTLLLYTA LRCSAPPTVS RCAPGKPTLV CSSAVGSWSY SQQRRQRVCS AESPPKTDLM AFSPSLQLSR EDCLNPPSEP RQPNPDWRYS ASLRAGMHSS VHLEEAGILR AGPGGPDQQW PTVSSATPEP EAGEVSPPVG AGVNSNSWTF KYGPGNPKQS GPGELPDKFI IPGSPAIISI RQEPTNSQID KSDFITFGKK EETKKKKKKK KGNKTQEKKE KGNSTTDNSD Q
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