About Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) is a protein
from Homo sapiens identified by UniProt accession
Q9UN76, 642 residues long.
MolForge cross-references it against 0 known binders and
135 disease associations.
Target properties
| Protein name | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) |
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| UniProt accession | Q9UN76 |
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| Gene | SLC6A14 |
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| Organism | Homo sapiens |
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| Length | 642 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (135)
Diseases linked to this target (Open Targets).
- cystic fibrosis · score 0.39
- obesity · score 0.37
- cutaneous melanoma · score 0.18
- ulcerative colitis · score 0.11
- neoplasm · score 0.09
- pachyonychia congenita · score 0.09
- Blackfan-Diamond anemia · score 0.08
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.08
- gonorrhea · score 0.07
- breast cancer · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UN76-F1 | alphafold | PREDICTED | 89.45 | — |
Amino-acid sequence (642 residues)
MDKLKCPSFF KCREKEKVSA SSENFHVGEN DENQDRGNWS KKSDYLLSMI GYAVGLGNVW RFPYLTYSNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA SLGPVSVWRI LPLFQGVGIT MVLISIFVTI YYNVIIAYSL YYMFASFQSE LPWKNCSSWS DKNCSRSPIV THCNVSTVNK GIQEIIQMNK SWVDINNFTC INGSEIYQPG QLPSEQYWNK VALQRSSGMN ETGVIVWYLA LCLLLAWLIV GAALFKGIKS SGKVVYFTAL FPYVVLLILL VRGATLEGAS KGISYYIGAQ SNFTKLKEAE VWKDAATQIF YSLSVAWGGL VALSSYNKFK NNCFSDAIVV CLTNCLTSVF AGFAIFSILG HMAHISGKEV SQVVKSGFDL AFIAYPEALA QLPGGPFWSI LFFFMLLTLG LDSQFASIET ITTTIQDLFP KVMKKMRVPI TLGCCLVLFL LGLVCVTQAG IYWVHLIDHF CAGWGILIAA ILELVGIIWI YGGNRFIEDT EMMIGAKRWI FWLWWRACWF VITPILLIAI FIWSLVQFHR PNYGAIPYPD WGVALGWCMI VFCIIWIPIM AIIKIIQAKG NIFQRLISCC RPASNWGPYL EQHRGERYKD MVDPKKEADH EIPTVSGSRK PE
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