About Ras GTPase-activating protein-binding protein 2
Ras GTPase-activating protein-binding protein 2 (G3BP2) is a protein
from Homo sapiens identified by UniProt accession
Q9UN86, 482 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Ras GTPase-activating protein-binding protein 2 |
|---|
| UniProt accession | Q9UN86 |
|---|
| Gene | G3BP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 482 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (75)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.37
- high density lipoprotein cholesterol measurement · score 0.29
- Red cell distribution width · score 0.16
- neoplasm · score 0.09
- hepatocellular carcinoma · score 0.08
- esophageal squamous cell carcinoma · score 0.08
- type 2 diabetes mellitus · score 0.07
- Testicular Germ Cell Tumor · score 0.06
- breast cancer · score 0.04
- C-X-C motif chemokine 10 measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UN86-F1 | alphafold | PREDICTED | 65.62 | — |
Amino-acid sequence (482 residues)
MVMEKPSPLL VGREFVRQYY TLLNKAPEYL HRFYGRNSSY VHGGVDASGK PQEAVYGQND IHHKVLSLNF SECHTKIRHV DAHATLSDGV VVQVMGLLSN SGQPERKFMQ TFVLAPEGSV PNKFYVHNDM FRYEDEVFGD SEPELDEESE DEVEEEQEER QPSPEPVQEN ANSGYYEAHP VTNGIEEPLE ESSHEPEPEP ESETKTEELK PQVEEKNLEE LEEKSTTPPP AEPVSLPQEP PKAFSWASVT SKNLPPSGTV SSSGIPPHVK APVSQPRVEA KPEVQSQPPR VREQRPRERP GFPPRGPRPG RGDMEQNDSD NRRIIRYPDS HQLFVGNLPH DIDENELKEF FMSFGNVVEL RINTKGVGGK LPNFGFVVFD DSEPVQRILI AKPIMFRGEV RLNVEEKKTR AARERETRGG GDDRRDIRRN DRGPGGPRGI VGGGMMRDRD GRGPPPRGGM AQKLGSGRGT GQMEGRFTGQ RR
Explore Ras GTPase-activating protein-binding protein 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets