About Gamma-aminobutyric acid receptor subunit theta
Gamma-aminobutyric acid receptor subunit theta (GABRQ) is a protein
from Homo sapiens identified by UniProt accession
Q9UN88, 632 residues long.
MolForge cross-references it against 0 known binders and
246 disease associations.
Target properties
| Protein name | Gamma-aminobutyric acid receptor subunit theta |
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| UniProt accession | Q9UN88 |
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| Gene | GABRQ |
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| Organism | Homo sapiens |
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| Length | 632 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (246)
Diseases linked to this target (Open Targets).
- epilepsy · score 0.60
- migraine disorder · score 0.60
- pain · score 0.60
- alcohol dependence · score 0.59
- delirium · score 0.59
- obesity · score 0.58
- coronary artery disease · score 0.58
- Seizure · score 0.58
- Agitation · score 0.57
- depressive disorder · score 0.57
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UN88-F1 | alphafold | PREDICTED | 66.39 | — |
Amino-acid sequence (632 residues)
MGIRGMLRAA VILLLIRTWL AEGNYPSPIP KFHFEFSSAV PEVVLNLFNC KNCANEAVVQ KILDRVLSRY DVRLRPNFGG APVPVRISIY VTSIEQISEM NMDYTITMFF HQTWKDSRLA YYETTLNLTL DYRMHEKLWV PDCYFLNSKD AFVHDVTVEN RVFQLHPDGT VRYGIRLTTT AACSLDLHKF PMDKQACNLV VESYGYTVED IILFWDDNGN AIHMTEELHI PQFTFLGRTI TSKEVYFYTG SYIRLILKFQ VQREVNSYLV QVYWPTVLTT ITSWISFWMN YDSSAARVTI GLTSMLILTT IDSHLRDKLP NISCIKAIDI YILVCLFFVF LSLLEYVYIN YLFYSRGPRR QPRRHRRPRR VIARYRYQQV VVGNVQDGLI NVEDGVSSLP ITPAQAPLAS PESLGSLTST SEQAQLATSE SLSPLTSLSG QAPLATGESL SDLPSTSEQA RHSYGVRFNG FQADDSIIPT EIRNRVEAHG HGVTHDHEDS NESLSSDERH GHGPSGKPML HHGEKGVQEA GWDLDDNNDK SDCLAIKEQF KCDTNSTWGL NDDELMAHGQ EKDSSSESED SCPPSPGCSF TEGFSFDLFN PDYVPKVDKW SRFLFPLAFG LFNIVYWVYH MY
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