About Nuclear pore complex-interacting protein family member A1
Nuclear pore complex-interacting protein family member A1 (NPIPA1) is a protein
from Homo sapiens identified by UniProt accession
Q9UND3, 350 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | Nuclear pore complex-interacting protein family member A1 |
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| UniProt accession | Q9UND3 |
|---|
| Gene | NPIPA1 |
|---|
| Organism | Homo sapiens |
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| Length | 350 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (42)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.11
- triglyceride measurement · score 0.11
- phosphatidylcholine measurement · score 0.10
- retinal nerve fibre layer thickness measurement · score 0.08
- diacylglycerol 38:3 measurement · score 0.08
- alkaline phosphatase measurement · score 0.07
- high density lipoprotein cholesterol measurement · score 0.07
- self reported educational attainment · score 0.07
- lipid measurement · score 0.06
- blood metabolite measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UND3-F1 | alphafold | PREDICTED | 51.16 | — |
Amino-acid sequence (350 residues)
MFCCLGYEWL SGGCKTWHSA WVINTLADHR HRGTDFGGSP WLLIITVFLR SYKFAISLCT SYLCVSFLKT IFPSQNGHDG STDVQQRARR SNRRRQEGIK IVLEDIFTLW RQVETKVRAK IRKMKVTTKV NRHDKINGKR KTAKEHLRKL SMKEREHGEK ERQVSEAEEN GKLDMKEIHT YMEMFQRAQA LRRRAEDYYR CKITPSARKP LCNRVRMAAV EHRHSSGLPY WPYLTAETLK NRMGHQPPPP TQQHSIIDNS LSLKTPSECL LTPLPPSALP SADDNLKTPA ECLLYPLPPS ADDNLKTPPE CLLTPLPPSA PPSVDDNLKT PPECVCSLPF HPQRMIISRN
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