About Tumor necrosis factor receptor superfamily member EDAR
Tumor necrosis factor receptor superfamily member EDAR (EDAR) is a protein
from Homo sapiens identified by UniProt accession
Q9UNE0, 448 residues long.
MolForge cross-references it against 0 known binders and
430 disease associations.
Target properties
| Protein name | Tumor necrosis factor receptor superfamily member EDAR |
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| UniProt accession | Q9UNE0 |
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| Gene | EDAR |
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| Organism | Homo sapiens |
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| Length | 448 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (430)
Diseases linked to this target (Open Targets).
- ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant · score 0.78
- autosomal recessive hypohidrotic ectodermal dysplasia · score 0.77
- hypohidrotic ectodermal dysplasia · score 0.73
- autosomal dominant hypohidrotic ectodermal dysplasia · score 0.58
- tooth agenesis · score 0.54
- genetic disorder · score 0.41
- Alpers syndrome · score 0.40
- mitochondrial DNA depletion syndrome 4a · score 0.40
- mitochondrial neurogastrointestinal encephalomyopathy · score 0.40
- tumor necrosis factor receptor superfamily member EDAR measurement · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UNE0-F1 | alphafold | PREDICTED | 66.56 | — |
Amino-acid sequence (448 residues)
MAHVGDCTQT PWLPVLVVSL MCSARAEYSN CGENEYYNQT TGLCQECPPC GPGEEPYLSC GYGTKDEDYG CVPCPAEKFS KGGYQICRRH KDCEGFFRAT VLTPGDMEND AECGPCLPGY YMLENRPRNI YGMVCYSCLL APPNTKECVG ATSGASANFP GTSGSSTLSP FQHAHKELSG QGHLATALII AMSTIFIMAI AIVLIIMFYI LKTKPSAPAC CTSHPGKSVE AQVSKDEEKK EAPDNVVMFS EKDEFEKLTA TPAKPTKSEN DASSENEQLL SRSVDSDEEP APDKQGSPEL CLLSLVHLAR EKSATSNKSA GIQSRRKKIL DVYANVCGVV EGLSPTELPF DCLEKTSRML SSTYNSEKAV VKTWRHLAES FGLKRDEIGG MTDGMQLFDR ISTAGYSIPE LLTKLVQIER LDAVESLCAD ILEWAGVVPP ASQPHAAS
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