About Rab effector Noc2
Rab effector Noc2 (RPH3AL) is a protein
from Homo sapiens identified by UniProt accession
Q9UNE2, 315 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Rab effector Noc2 |
|---|
| UniProt accession | Q9UNE2 |
|---|
| Gene | RPH3AL |
|---|
| Organism | Homo sapiens |
|---|
| Length | 315 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (55)
Diseases linked to this target (Open Targets).
- benign lipomatous neoplasm · score 0.39
- IGF-1 measurement · score 0.29
- drug use measurement · score 0.15
- primary ovarian insufficiency · score 0.12
- MODY · score 0.08
- diabetes mellitus, transient neonatal, 2 · score 0.05
- exercise-induced hyperinsulinism · score 0.05
- type 2 diabetes mellitus · score 0.05
- type 1 diabetes mellitus · score 0.05
- chronic pancreatitis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UNE2-F1 | alphafold | PREDICTED | 67.44 | — |
Amino-acid sequence (315 residues)
MADTIFGSGN DQWVCPNDRQ LALRAKLQTG WSVHTYQTEK QRRKQHLSPA EVEAILQVIQ RAERLDVLEQ QRIGRLVERL ETMRRNVMGN GLSQCLLCGE VLGFLGSSSV FCKDCRKKVC TKCGIEASPG QKRPLWLCKI CSEQREVWKR SGAWFYKGLP KYILPLKTPG RADDPHFRPL PTEPAEREPR SSETSRIYTW ARGRVVSSDS DSDSDLSSSS LEDRLPSTGV RDRKGDKPWK ESGGSVEAPR MGFTHPPGHL SGCQSSLASG ETGTGSADPP GGPRPGLTRR APVKDTPGRA PAADAAPAGP SSCLG
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