E3 ubiquitin-protein ligase CHIP (STUB1)

About E3 ubiquitin-protein ligase CHIP

E3 ubiquitin-protein ligase CHIP (STUB1) is a protein from Homo sapiens identified by UniProt accession Q9UNE7, 303 residues long. MolForge cross-references it against 0 known binders and 567 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase CHIP
UniProt accession	Q9UNE7
Gene	STUB1
Organism	Homo sapiens
Length	303 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (567)

Diseases linked to this target (Open Targets).

autosomal recessive spinocerebellar ataxia 16 · score 0.82
spinocerebellar ataxia 48 · score 0.75
glioblastoma multiforme · score 0.24
lung adenocarcinoma · score 0.24
endometrial cancer · score 0.18
thyroid gland adenocarcinoma · score 0.18
genetic disorder · score 0.18
blood protein measurement · score 0.17
head and neck squamous cell carcinoma · score 0.13
neoplasm · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UNE7-F1	alphafold	PREDICTED	89.28	—

Amino-acid sequence (303 residues)

MKGKEEKEGG ARLGAGGGSP EKSPSAQELK EQGNRLFVGR KYPEAAACYG RAITRNPLVA VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL GQCQLEMESY DEAIANLQRA YSLAKEQRLN FGDDIPSALR IAKKKRWNSI EERRIHQESE LHSYLSRLIA AERERELEEC QRNHEGDEDD SHVRAQQACI EAKHDKYMAD MDELFSQVDE KRKKRDIPDY LCGKISFELM REPCITPSGI TYDRKDIEEH LQRVGHFDPV TRSPLTQEQL IPNLAMKEVI DAFISENGWV EDY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards