About Protein kinase C and casein kinase substrate in neurons protein 2
Protein kinase C and casein kinase substrate in neurons protein 2 (PACSIN2) is a protein
from Homo sapiens identified by UniProt accession
Q9UNF0, 486 residues long.
MolForge cross-references it against 0 known binders and
145 disease associations.
Target properties
| Protein name | Protein kinase C and casein kinase substrate in neurons protein 2 |
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| UniProt accession | Q9UNF0 |
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| Gene | PACSIN2 |
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| Organism | Homo sapiens |
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| Length | 486 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (145)
Diseases linked to this target (Open Targets).
- platelet count · score 0.43
- platelet component distribution width · score 0.43
- mean platelet volume · score 0.41
- neurodegenerative disease · score 0.37
- body height · score 0.23
- self reported educational attainment · score 0.21
- reticulocyte count · score 0.17
- platelet-to-lymphocyte ratio · score 0.15
- sitting height measurement · score 0.13
- primary ovarian insufficiency · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UNF0-F1 | alphafold | PREDICTED | 81.30 | — |
Amino-acid sequence (486 residues)
MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCSD LMNCLHERAR IEKAYAQQLT EWARRWRQLV EKGPQYGTVE KAWMAFMSEA ERVSELHLEV KASLMNDDFE KIKNWQKEAF HKQMMGGFKE TKEAEDGFRK AQKPWAKKLK EVEAAKKAHH AACKEEKLAI SREANSKADP SLNPEQLKKL QDKIEKCKQD VLKTKEKYEK SLKELDQGTP QYMENMEQVF EQCQQFEEKR LRFFREVLLE VQKHLDLSNV AGYKAIYHDL EQSIRAADAV EDLRWFRANH GPGMAMNWPQ FEEWSADLNR TLSRREKKKA TDGVTLTGIN QTGDQSLPSK PSSTLNVPSN PAQSAQSQSS YNPFEDEDDT GSTVSEKDDT KAKNVSSYEK TQSYPTDWSD DESNNPFSST DANGDSNPFD DDATSGTEVR VRALYDYEGQ EHDELSFKAG DELTKMEDED EQGWCKGRLD NGQVGLYPAN YVEAIQ
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