About Melanoma-associated antigen D2
Melanoma-associated antigen D2 (MAGED2) is a protein
from Homo sapiens identified by UniProt accession
Q9UNF1, 606 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Melanoma-associated antigen D2 |
|---|
| UniProt accession | Q9UNF1 |
|---|
| Gene | MAGED2 |
|---|
| Organism | Homo sapiens |
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| Length | 606 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (55)
Diseases linked to this target (Open Targets).
- Bartter syndrome · score 0.52
- Bartter syndrome with hypocalcemia · score 0.37
- neurodegenerative disease · score 0.37
- Cerebellar atrophy · score 0.26
- Hypotonia · score 0.26
- Dandy-Walker syndrome · score 0.26
- Global developmental delay · score 0.26
- Hypoplasia of the corpus callosum · score 0.26
- attention deficit hyperactivity disorder · score 0.26
- breast adenocarcinoma · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UNF1-F1 | alphafold | PREDICTED | 58.31 | — |
Amino-acid sequence (606 residues)
MSDTSESGAG LTRFQAEASE KDSSSMMQTL LTVTQNVEVP ETPKASKALE VSEDVKVSKA SGVSKATEVS KTPEAREAPA TQASSTTQLT DTQVLAAENK SLAADTKKQN ADPQAVTMPA TETKKVSHVA DTKVNTKAQE TEAAPSQAPA DEPEPESAAA QSQENQDTRP KVKAKKARKV KHLDGEEDGS SDQSQASGTT GGRRVSKALM ASMARRASRG PIAFWARRAS RTRLAAWARR ALLSLRSPKA RRGKARRRAA KLQSSQEPEA PPPRDVALLQ GRANDLVKYL LAKDQTKIPI KRSDMLKDII KEYTDVYPEI IERAGYSLEK VFGIQLKEID KNDHLYILLS TLEPTDAGIL GTTKDSPKLG LLMVLLSIIF MNGNRSSEAV IWEVLRKLGL RPGIHHSLFG DVKKLITDEF VKQKYLDYAR VPNSNPPEYE FFWGLRSYYE TSKMKVLKFA CKVQKKDPKE WAAQYREAME ADLKAAAEAA AEAKARAEIR ARMGIGLGSE NAAGPCNWDE ADIGPWAKAR IQAGAEAKAK AQESGSASTG ASTSTNNSAS ASASTSGGFS AGASLTATLT FGLFAGLGGA GASTSGSSGA CGFSYK
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