Tumor necrosis factor ligand superfamily member 18…

About Tumor necrosis factor ligand superfamily member 18

Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is a protein from Homo sapiens identified by UniProt accession Q9UNG2, 177 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

Target properties

Protein name	Tumor necrosis factor ligand superfamily member 18
UniProt accession	Q9UNG2
Gene	TNFSF18
Organism	Homo sapiens
Length	177 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

Crohn's disease · score 0.39
celiac disease · score 0.27
inflammatory bowel disease · score 0.27
rheumatoid arthritis · score 0.25
psoriasis · score 0.25
ankylosing spondylitis · score 0.25
sclerosing cholangitis · score 0.25
ulcerative colitis · score 0.25
atopic eczema · score 0.24
protein measurement · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UNG2-F1	alphafold	PREDICTED	86.72	—

Amino-acid sequence (177 residues)

MCLSHLENMP LSHSRTQGAQ RSSWKLWLFC SIVMLLFLCS FSWLIFIFLQ LETAKEPCMA KFGPLPSKWQ MASSEPPCVN KVSDWKLEIL QNGLYLIYGQ VAPNANYNDV APFEVRLYKN KDMIQTLTNK SKIQNVGGTY ELHVGDTIDL IFNSEHQVLK NNTYWGIILL ANPQFIS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Tumor necrosis factor ligand superfamily member 18 (TNFSF18)