About Sorting nexin-6
Sorting nexin-6 (SNX6) is a protein
from Homo sapiens identified by UniProt accession
Q9UNH7, 406 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Sorting nexin-6 |
|---|
| UniProt accession | Q9UNH7 |
|---|
| Gene | SNX6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 406 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.26
- neurodegenerative disease · score 0.25
- diastolic blood pressure · score 0.21
- insulin measurement · score 0.08
- BMI-adjusted waist-hip ratio · score 0.05
- waist-hip ratio · score 0.05
- cholesterol-ester transfer protein deficiency · score 0.05
- hypertriglyceridemia 2 · score 0.05
- Combined hyperlipidemia · score 0.04
- thyroid hormone metabolism, abnormal, 2 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UNH7-F1 | alphafold | PREDICTED | 88.81 | — |
Amino-acid sequence (406 residues)
MMEGLDDGPD FLSEEDRGLK AINVDLQSDA ALQVDISDAL SERDKVKFTV HTKSSLPNFK QNEFSVVRQH EEFIWLHDSF VENEDYAGYI IPPAPPRPDF DASREKLQKL GEGEGSMTKE EFTKMKQELE AEYLAIFKKT VAMHEVFLCR VAAHPILRRD LNFHVFLEYN QDLSVRGKNK KEKLEDFFKN MVKSADGVIV SGVKDVDDFF EHERTFLLEY HNRVKDASAK SDRMTRSHKS AADDYNRIGS SLYALGTQDS TDICKFFLKV SELFDKTRKI EARVSADEDL KLSDLLKYYL RESQAAKDLL YRRSRSLVDY ENANKALDKA RAKNKDVLQA ETSQQLCCQK FEKISESAKQ ELIDFKTRRV AAFRKNLVEL AELELKHAKG NLQLLQNCLA VLNGDT
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