About Syntaxin-8
Syntaxin-8 (STX8) is a protein
from Homo sapiens identified by UniProt accession
Q9UNK0, 236 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Syntaxin-8 |
|---|
| UniProt accession | Q9UNK0 |
|---|
| Gene | STX8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 236 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (85)
Diseases linked to this target (Open Targets).
- white matter microstructure measurement · score 0.26
- Limb pain · score 0.26
- asthma · score 0.25
- uric acid measurement · score 0.24
- blood protein measurement · score 0.24
- protein measurement · score 0.23
- cortical surface area measurement · score 0.23
- gut microbiome measurement · score 0.21
- body height · score 0.20
- cortical thickness · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UNK0-F1 | alphafold | PREDICTED | 76.34 | — |
Amino-acid sequence (236 residues)
MAPDPWFSTY DSTCQIAQEI AEKIQQRNQY ERKGEKAPKL TVTIRALLQN LKEKIALLKD LLLRAVSTHQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE GAEPDLIRSS LMSEEAKRGA PNPWLFEEPE ETRGLGFDEI RQQQQKIIQE QDAGLDALSS IISRQKQMGQ EIGNELDEQN EIIDDLANLV ENTDEKLRNE TRRVNMVDRK SASCGMIMVI LLLLVAIVVV AVWPTN
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