About Group IID secretory phospholipase A2
Group IID secretory phospholipase A2 (PLA2G2D) is a protein
from Homo sapiens identified by UniProt accession
Q9UNK4, 145 residues long.
MolForge cross-references it against 0 known binders and
211 disease associations.
Target properties
| Protein name | Group IID secretory phospholipase A2 |
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| UniProt accession | Q9UNK4 |
|---|
| Gene | PLA2G2D |
|---|
| Organism | Homo sapiens |
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| Length | 145 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (211)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.18
- cutaneous melanoma · score 0.10
- telomere length · score 0.06
- polyunsaturated fatty acid measurement · score 0.06
- isolated agammaglobulinemia · score 0.05
- common variable immunodeficiency · score 0.05
- T-B+ severe combined immunodeficiency due to JAK3 deficiency · score 0.05
- immunodeficiency 18 · score 0.05
- Immunodeficiency by defective expression of HLA class 2 · score 0.04
- attention deficit hyperactivity disorder · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UNK4-F1 | alphafold | PREDICTED | 91.51 | — |
Amino-acid sequence (145 residues)
MELALLCGLV VMAGVIPIQG GILNLNKMVK QVTGKMPILS YWPYGCHCGL GGRGQPKDAT DWCCQTHDCC YDHLKTQGCS IYKDYYRYNF SQGNIHCSDK GSWCEQQLCA CDKEVAFCLK RNLDTYQKRL RFYWRPHCRG QTPGC
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