Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5)

About Lactosylceramide alpha-2,3-sialyltransferase

Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5) is a protein from Homo sapiens identified by UniProt accession Q9UNP4, 418 residues long. MolForge cross-references it against 0 known binders and 152 disease associations.

Target properties

Protein name	Lactosylceramide alpha-2,3-sialyltransferase
UniProt accession	Q9UNP4
Gene	ST3GAL5
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (152)

Diseases linked to this target (Open Targets).

GM3 synthase deficiency · score 0.80
Intellectual disability · score 0.50
mean corpuscular volume · score 0.39
mean platelet volume · score 0.37
Red cell distribution width · score 0.37
Developmental regression · score 0.37
erythrocyte count · score 0.35
genetic disorder · score 0.34
testosterone measurement · score 0.32
monocyte percentage of leukocytes · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UNP4-F1	alphafold	PREDICTED	83.13	—

Amino-acid sequence (418 residues)

MRTKAAGCAE RRPLQPRTEA AAAPAGRAMP SEYTYVKLRS DCSRPSLQWY TRAQSKMRRP SLLLKDILKC TLLVFGVWIL YILKLNYTTE ECDMKKMHYV DPDHVKRAQK YAQQVLQKEC RPKFAKTSMA LLFEHRYSVD LLPFVQKAPK DSEAESKYDP PFGFRKFSSK VQTLLELLPE HDLPEHLKAK TCRRCVVIGS GGILHGLELG HTLNQFDVVI RLNSAPVEGY SEHVGNKTTI RMTYPEGAPL SDLEYYSNDL FVAVLFKSVD FNWLQAMVKK ETLPFWVRLF FWKQVAEKIP LQPKHFRILN PVIIKETAFD ILQYSEPQSR FWGRDKNVPT IGVIAVVLAT HLCDEVSLAG FGYDLNQPRT PLHYFDSQCM AAMNFQTMHN VTTETKFLLK LVKEGVVKDL SGGIDREF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards