Peptidyl-prolyl cis-trans isomerase E (PPIE)

About Peptidyl-prolyl cis-trans isomerase E

Peptidyl-prolyl cis-trans isomerase E (PPIE) is a protein from Homo sapiens identified by UniProt accession Q9UNP9, 301 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Peptidyl-prolyl cis-trans isomerase E
UniProt accession	Q9UNP9
Gene	PPIE
Organism	Homo sapiens
Length	301 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.16
heel bone mineral density · score 0.15
peptidyl-prolyl cis-trans isomerase E measurement · score 0.13
diabetes mellitus · score 0.08
hemoglobin E-beta-thalassemia syndrome · score 0.06
Adult-onset autosomal recessive sideroblastic anemia · score 0.05
hemoglobin D disease · score 0.05
hemochromatosis type 5 · score 0.05
FTH1-related iron overload · score 0.05
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UNP9-F1	alphafold	PREDICTED	83.20	—

Amino-acid sequence (301 residues)

MATTKRVLYV GGLAEEVDDK VLHAAFIPFG DITDIQIPLD YETEKHRGFA FVEFELAEDA AAAIDNMNES ELFGRTIRVN LAKPMRIKEG SSRPVWSDDD WLKKFSGKTL EENKEEEGSE PPKAETQEGE PIAKKARSNP QVYMDIKIGN KPAGRIQMLL RSDVVPMTAE NFRCLCTHEK GFGFKGSSFH RIIPQFMCQG GDFTNHNGTG GKSIYGKKFD DENFILKHTG PGLLSMANSG PNTNGSQFFL TCDKTDWLDG KHVVFGEVTE GLDVLRQIEA QGSKDGKPKQ KVIIADCGEY V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards