Dimethyladenosine transferase (DIMT1)

About Dimethyladenosine transferase

Dimethyladenosine transferase (DIMT1) is a protein from Homo sapiens identified by UniProt accession Q9UNQ2, 313 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	Dimethyladenosine transferase
UniProt accession	Q9UNQ2
Gene	DIMT1
Organism	Homo sapiens
Length	313 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
lysosomal storage disease · score 0.45
Alzheimer disease · score 0.45
multiple sclerosis · score 0.45
Parkinson disease · score 0.45
mean corpuscular volume · score 0.26
mean reticulocyte volume · score 0.22
mean platelet volume · score 0.21
mean corpuscular hemoglobin concentration · score 0.20
sex hormone-binding globulin measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UNQ2-F1	alphafold	PREDICTED	92.00	—

Amino-acid sequence (313 residues)

MPKVKSGAIG RRRGRQEQRR ELKSAGGLMF NTGIGQHILK NPLIINSIID KAALRPTDVV LEVGPGTGNM TVKLLEKAKK VVACELDPRL VAELHKRVQG TPVASKLQVL VGDVLKTDLP FFDTCVANLP YQISSPFVFK LLLHRPFFRC AILMFQREFA LRLVAKPGDK LYCRLSINTQ LLARVDHLMK VGKNNFRPPP KVESSVVRIE PKNPPPPINF QEWDGLVRIT FVRKNKTLSA AFKSSAVQQL LEKNYRIHCS VHNIIIPEDF SIADKIQQIL TSTGFSDKRA RSMDIDDFIR LLHGFNAEGI HFS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards