COP9 signalosome complex subunit 3 (COPS3)

About COP9 signalosome complex subunit 3

COP9 signalosome complex subunit 3 (COPS3) is a protein from Homo sapiens identified by UniProt accession Q9UNS2, 423 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.

Target properties

Protein name	COP9 signalosome complex subunit 3
UniProt accession	Q9UNS2
Gene	COPS3
Organism	Homo sapiens
Length	423 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (55)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.42
heel bone mineral density · score 0.31
reticulocyte count · score 0.29
mean corpuscular volume · score 0.29
glioblastoma multiforme · score 0.23
mean reticulocyte volume · score 0.22
lung adenocarcinoma · score 0.18
breast adenocarcinoma · score 0.18
neutrophil percentage of leukocytes · score 0.15
diet measurement · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UNS2-F1	alphafold	PREDICTED	84.22	—

Amino-acid sequence (423 residues)

MASALEQFVN SVRQLSAQGQ MTQLCELINK SGELLAKNLS HLDTVLGALD VQEHSLGVLA VLFVKFSMPS VPDFETLFSQ VQLFISTCNG EHIRYATDTF AGLCHQLTNA LVERKQPLRG IGILKQAIDK MQMNTNQLTS IHADLCQLCL LAKCFKPALP YLDVDMMDIC KENGAYDAKH FLCYYYYGGM IYTGLKNFER ALYFYEQAIT TPAMAVSHIM LESYKKYILV SLILLGKVQQ LPKYTSQIVG RFIKPLSNAY HELAQVYSTN NPSELRNLVN KHSETFTRDN NMGLVKQCLS SLYKKNIQRL TKTFLTLSLQ DMASRVQLSG PQEAEKYVLH MIEDGEIFAS INQKDGMVSF HDNPEKYNNP AMLHNIDQEM LKCIELDERL KAMDQEITVN PQFVQKSMGS QEDDSGNKPS SYS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards