Probable G-protein coupled receptor 132 (GPR132)

About Probable G-protein coupled receptor 132

Probable G-protein coupled receptor 132 (GPR132) is a protein from Homo sapiens identified by UniProt accession Q9UNW8, 380 residues long. MolForge cross-references it against 0 known binders and 246 disease associations.

Target properties

Protein name	Probable G-protein coupled receptor 132
UniProt accession	Q9UNW8
Gene	GPR132
Organism	Homo sapiens
Length	380 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (246)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
glioblastoma multiforme · score 0.25
ovarian cancer · score 0.24
breast adenocarcinoma · score 0.24
low grade glioma · score 0.12
creatinine measurement · score 0.10
prostate adenocarcinoma · score 0.10
neoplasm · score 0.08
acute myeloid leukemia · score 0.08
cancer · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UNW8-F1	alphafold	PREDICTED	79.51	—

Amino-acid sequence (380 residues)

MCPMLLKNGY NGNATPVTTT APWASLGLSA KTCNNVSFEE SRIVLVVVYS AVCTLGVPAN CLTAWLALLQ VLQGNVLAVY LLCLALCELL YTGTLPLWVI YIRNQHRWTL GLLACKVTAY IFFCNIYVSI LFLCCISCDR FVAVVYALES RGRRRRRTAI LISACIFILV GIVHYPVFQT EDKETCFDML QMDSRIAGYY YARFTVGFAI PLSIIAFTNH RIFRSIKQSM GLSAAQKAKV KHSAIAVVVI FLVCFAPYHL VLLVKAAAFS YYRGDRNAMC GLEERLYTAS VVFLCLSTVN GVADPIIYVL ATDHSRQEVS RIHKGWKEWS MKTDVTRLTH SRDTEELQSP VALADHYTFS RPVHPPGSPC PAKRLIEESC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards