About WD repeat-containing protein 3
WD repeat-containing protein 3 (WDR3) is a protein
from Homo sapiens identified by UniProt accession
Q9UNX4, 943 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | WD repeat-containing protein 3 |
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| UniProt accession | Q9UNX4 |
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| Gene | WDR3 |
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| Organism | Homo sapiens |
|---|
| Length | 943 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- age-related hearing impairment · score 0.23
- neurodegenerative disease · score 0.14
- endometrial cancer · score 0.10
- pancreatic neoplasm · score 0.07
- attention deficit-hyperactivity disorder 8 · score 0.07
- attention deficit hyperactivity disorder · score 0.07
- schizophrenia 15 · score 0.07
- reticulocyte count · score 0.07
- myeloid white cell count · score 0.07
- schizophrenia · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UNX4-F1 | alphafold | PREDICTED | 84.74 | — |
Amino-acid sequence (943 residues)
MGLTKQYLRY VASAVFGVIG SQKGNIVFVT LRGEKGRYVA VPACEHVFIW DLRKGEKILI LQGLKQEVTC LCPSPDGLHL AVGYEDGSIR IFSLLSGEGN VTFNGHKAAI TTLKYDQLGG RLASGSKDTD IIVWDVINES GLYRLKGHKD AITQALFLRE KNLLVTSGKD TMVKWWDLDT QHCFKTMVGH RTEVWGLVLL SEEKRLITGA SDSELRVWDI AYLQEIEDPE EPDPKKIKGS SPGIQDTLEA EDGAFETDEA PEDRILSCRK AGSIMREGRD RVVNLAVDKT GRILACHGTD SVLELFCILS KKEIQKKMDK KMKKARKKAK LHSSKGEEED PEVNVEMSLQ DEIQRVTNIK TSAKIKSFDL IHSPHGELKA VFLLQNNLVE LYSLNPSLPT PQPVRTSRIT IGGHRSDVRT LSFSSDNIAV LSAAADSIKI WNRSTLQCIR TMTCEYALCS FFVPGDRQVV IGTKTGKLQL YDLASGNLLE TIDAHDGALW SMSLSPDQRG FVTGGADKSV KFWDFELVKD ENSTQKRLSV KQTRTLQLDE DVLCVSYSPN QKLLAVSLLD CTVKIFYVDT LKFFLSLYGH KLPVICMDIS HDGALIATGS ADRNVKIWGL DFGDCHKSLF AHDDSVMYLQ FVPKSHLFFT AGKDHKIKQW DADKFEHIQT LEGHHQEIWC LAVSPSGDYV VSSSHDKSLR LWERTREPLI LEEEREMERE AEYEESVAKE DQPAVPGETQ GDSYFTGKKT IETVKAAERI MEAIELYREE TAKMKEHKAI CKAAGKEVPL PSNPILMAYG SISPSAYVLE IFKGIKSSEL EESLLVLPFS YVPDILKLFN EFIQLGSDVE LICRCLFFLL RIHFGQITSN QMLVPVIEKL RETTISKVSQ VRDVIGFNMA GLDYLKRECE AKSEVMFFAD ATSHLEEKKR KRKKREKLIL TLT
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