About Cytosolic phospholipase A2 gamma
Cytosolic phospholipase A2 gamma (PLA2G4C) is a protein
from Homo sapiens identified by UniProt accession
Q9UP65, 541 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Cytosolic phospholipase A2 gamma |
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| UniProt accession | Q9UP65 |
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| Gene | PLA2G4C |
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| Organism | Homo sapiens |
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| Length | 541 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (50)
Diseases linked to this target (Open Targets).
- optic cup area measurement · score 0.18
- breast adenocarcinoma · score 0.18
- cutaneous melanoma · score 0.14
- neurofibrillary tangles measurement · score 0.03
- testosterone measurement · score 0.03
- body height · score 0.02
- atypical teratoid rhabdoid tumor · score 0.02
- non-small cell lung carcinoma · score 0.01
- cystic fibrosis · score 0.01
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UP65-F1 | alphafold | PREDICTED | 84.03 | — |
Amino-acid sequence (541 residues)
MGSSEVSIIP GLQKEEKAAV ERRRLHVLKA LKKLRIEADE APVVAVLGSG GGLRAHIACL GVLSEMKEQG LLDAVTYLAG VSGSTWAISS LYTNDGDMEA LEADLKHRFT RQEWDLAKSL QKTIQAARSE NYSLTDFWAY MVISKQTREL PESHLSNMKK PVEEGTLPYP IFAAIDNDLQ PSWQEARAPE TWFEFTPHHA GFSALGAFVS ITHFGSKFKK GRLVRTHPER DLTFLRGLWG SALGNTEVIR EYIFDQLRNL TLKGLWRRAV ANAKSIGHLI FARLLRLQES SQGEHPPPED EGGEPEHTWL TEMLENWTRT SLEKQEQPHE DPERKGSLSN LMDFVKKTGI CASKWEWGTT HNFLYKHGGI RDKIMSSRKH LHLVDAGLAI NTPFPLVLPP TREVHLILSF DFSAGDPFET IRATTDYCRR HKIPFPQVEE AELDLWSKAP ASCYILKGET GPVVMHFPLF NIDACGGDIE AWSDTYDTFK LADTYTLDVV VLLLALAKKN VRENKKKILR ELMNVAGLYY PKDSARSCCL A
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