About Conserved oligomeric Golgi complex subunit 5
Conserved oligomeric Golgi complex subunit 5 (COG5) is a protein
from Homo sapiens identified by UniProt accession
Q9UP83, 860 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Conserved oligomeric Golgi complex subunit 5 |
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| UniProt accession | Q9UP83 |
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| Gene | COG5 |
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| Organism | Homo sapiens |
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| Length | 860 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (69)
Diseases linked to this target (Open Targets).
- COG5-congenital disorder of glycosylation · score 0.80
- neurodegenerative disease · score 0.53
- genetic disorder · score 0.41
- vitamin D measurement · score 0.28
- alkaline phosphatase measurement · score 0.27
- monocyte count · score 0.21
- coronary artery disease · score 0.19
- smoking status measurement · score 0.17
- apolipoprotein A 1 measurement · score 0.16
- high density lipoprotein cholesterol measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UP83-F1 | alphafold | PREDICTED | 83.61 | — |
Amino-acid sequence (860 residues)
MGWVGGRRRD SASPPGRSRS AADDINPAPA NMEGGGGSVA VAGLGARGSG AAAATVRELL QDGCYSDFLN EDFDVKTYTS QSIHQAVIAE QLAKLAQGIS QLDRELHLQV VARHEDLLAQ ATGIESLEGV LQMMQTRIGA LQGAVDRIKA KIVEPYNKIV ARTAQLARLQ VACDLLRRII RILNLSKRLQ GQLQGGSREI TKAAQSLNEL DYLSQGIDLS GIEVIENDLL FIARARLEVE NQAKRLLEQG LETQNPTQVG TALQVFYNLG TLKDTITSVV DGYCATLEEN INSALDIKVL TQPSQSAVRG GPGRSTMPTP GNTAALRASF WTNMEKLMDH IYAVCGQVQH LQKVLAKKRD PVSHICFIEE IVKDGQPEIF YTFWNSVTQA LSSQFHMATN SSMFLKQAFE GEYPKLLRLY NDLWKRLQQY SQHIQGNFNA SGTTDLYVDL QHMEDDAQDI FIPKKPDYDP EKALKDSLQP YEAAYLSKSL SRLFDPINLV FPPGGRNPPS SDELDGIIKT IASELNVAAV DTNLTLAVSK NVAKTIQLYS VKSEQLLSTQ GDASQVIGPL TEGQRRNVAV VNSLYKLHQS VTKVVSSQSS FPLAAEQTII SALKAIHALM ENAVQPLLTS VGDAIEAIII TMHQEDFSGS LSSSGKPDVP CSLYMKELQG FIARVMSDYF KHFECLDFVF DNTEAIAQRA VELFIRHASL IRPLGEGGKM RLAADFAQME LAVGPFCRRV SDLGKSYRML RSFRPLLFQA SEHVASSPAL GDVIPFSIII QFLFTRAPAE LKSPFQRAEW SHTRFSQWLD DHPSEKDRLL LIRGALEAYV QSVRSREGKE FAPVYPIMVQ LLQKAMSALQ
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