LIM/homeobox protein Lhx6 (LHX6)

About LIM/homeobox protein Lhx6

LIM/homeobox protein Lhx6 (LHX6) is a protein from Homo sapiens identified by UniProt accession Q9UPM6, 363 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.

Target properties

Protein name	LIM/homeobox protein Lhx6
UniProt accession	Q9UPM6
Gene	LHX6
Organism	Homo sapiens
Length	363 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (105)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.37
neurodegenerative disease · score 0.28
multiple sclerosis · score 0.28
Alzheimer disease · score 0.28
lysosomal storage disease · score 0.28
Parkinson disease · score 0.28
neoplasm · score 0.08
Generalized epilepsy with febrile seizures-plus · score 0.06
generalised epilepsy · score 0.06
juvenile myoclonic epilepsy · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UPM6-F1	alphafold	PREDICTED	67.12	—

Amino-acid sequence (363 residues)

MAQPGSGCKA TTRCLEGTAP PAMAQSDAEA LAGALDKDEG QASPCTPSTP SVCSPPSAAS SVPSAGKNIC SSCGLEILDR YLLKVNNLIW HVRCLECSVC RTSLRQQNSC YIKNKEIFCK MDYFSRFGTK CARCGRQIYA SDWVRRARGN AYHLACFACF SCKRQLSTGE EFGLVEEKVL CRIHYDTMIE NLKRAAENGN GLTLEGAVPS EQDSQPKPAK RARTSFTAEQ LQVMQAQFAQ DNNPDAQTLQ KLADMTGLSR RVIQVWFQNC RARHKKHTPQ HPVPPSGAPP SRLPSALSDD IHYTPFSSPE RARMVTLHGY IESQVQCGQV HCRLPYTAPP VHLKADMDGP LSNRGEKVIL FQY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards