About LIM and calponin homology domains-containing protein 1
LIM and calponin homology domains-containing protein 1 (LIMCH1) is a protein
from Homo sapiens identified by UniProt accession
Q9UPQ0, 1083 residues long.
MolForge cross-references it against 0 known binders and
189 disease associations.
Target properties
| Protein name | LIM and calponin homology domains-containing protein 1 |
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| UniProt accession | Q9UPQ0 |
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| Gene | LIMCH1 |
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| Organism | Homo sapiens |
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| Length | 1083 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (189)
Diseases linked to this target (Open Targets).
- leukocyte count · score 0.39
- macula measurement · score 0.34
- neutrophil count · score 0.31
- optic disc size measurement · score 0.29
- myeloid white cell count · score 0.26
- coronary atherosclerosis · score 0.25
- glomerular filtration rate · score 0.23
- red blood cell density measurement · score 0.22
- creatinine measurement · score 0.15
- lung adenocarcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UPQ0-F1 | alphafold | PREDICTED | 55.62 | — |
Amino-acid sequence (1083 residues)
MACPALGLEA LQPLQPEPPP EPAFSEAQKW IEQVTGRSFG DKDFRTGLEN GILLCELLNA IKPGLVKKIN RLPTPIAGLD NIILFLRGCK ELGLKESQLF DPSDLQDTSN RVTVKSLDYS RKLKNVLVTI YWLGKAANSC TSYSGTTLNL KEFEGLLAQM RKDTDDIESP KRSIRDSGYI DCWDSERSDS LSPPRHGRDD SFDSLDSFGS RSRQTPSPDV VLRGSSDGRG SDSESDLPHR KLPDVKKDDM SARRTSHGEP KSAVPFNQYL PNKSNQTAYV PAPLRKKKAE REEYRKSWST ATSPLGGERP FRYGPRTPVS DDAESTSMFD MRCEEEAAVQ PHSRARQEQL QLINNQLREE DDKWQDDLAR WKSRRRSVSQ DLIKKEEERK KMEKLLAGED GTSERRKSIK TYREIVQEKE RRERELHEAY KNARSQEEAE GILQQYIERF TISEAVLERL EMPKILERSH STEPNLSSFL NDPNPMKYLR QQSLPPPKFT ATVETTIARA SVLDTSMSAG SGSPSKTVTP KAVPMLTPKP YSQPKNSQDV LKTFKVDGKV SVNGETVHRE EEKERECPTV APAHSLTKSQ MFEGVARVHG SPLELKQDNG SIEINIKKPN SVPQELAATT EKTEPNSQED KNDGGKSRKG NIELASSEPQ HFTTTVTRCS PTVAFVEFPS SPQLKNDVSE EKDQKKPENE MSGKVELVLS QKVVKPKSPE PEATLTFPFL DKMPEANQLH LPNLNSQVDS PSSEKSPVMT PQFKFWAWDP EEERRRQEKW QQEQERLLQE RYQKEQDKLK EEWEKAQKEV EEEERRYYEE ERKIIEDTVV PFTVSSSSAD QLSTSSSMTE GSGTMNKIDL GNCQDEKQDR RWKKSFQGDD SDLLLKTRES DRLEEKGSLT EGALAHSGNP VSKGVHEDHQ LDTEAGAPHC GTNPQLAQDP SQNQQTSNPT HSSEDVKPKT LPLDKSINHQ IESPSERRKK SPREHFQAGP FSPCSPTPPG QSPNRSISGK KLCSSCGLPL GKGAAMIIET LNLYFHIQCF RCGICKGQLG DAVSGTDVRI RNGLLNCNDC YMRSRSAGQP TTL
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