About Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP1) is a protein
from Homo sapiens identified by UniProt accession
Q9UPQ3, 857 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 |
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| UniProt accession | Q9UPQ3 |
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| Gene | AGAP1 |
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| Organism | Homo sapiens |
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| Length | 857 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (105)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.43
- mean corpuscular hemoglobin · score 0.41
- Red cell distribution width · score 0.41
- body height · score 0.40
- erythrocyte count · score 0.39
- self reported educational attainment · score 0.37
- mean corpuscular hemoglobin concentration · score 0.37
- body mass index · score 0.37
- red blood cell density measurement · score 0.34
- cortical surface area measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UPQ3-F1 | alphafold | PREDICTED | 71.00 | — |
Amino-acid sequence (857 residues)
MNYQQQLANS AAIRAEIQRF ESVHPNIYSI YELLERVEEP VLQNQIREHV IAIEDAFVNS QEWTLSRSVP ELKVGIVGNL ASGKSALVHR YLTGTYVQEE SPEGGRFKKE IVVDGQSYLL LIRDEGGPPE AQFAMWVDAV IFVFSLEDEI SFQTVYHYYS RMANYRNTSE IPLVLVGTQD AISSANPRVI DDARARKLSN DLKRCTYYET CATYGLNVER VFQDVAQKIV ATRKKQQLSI GPCKSLPNSP SHSSVCSAQV SAVHISQTSN GGGSLSDYSS SVPSTPSTSQ KELRIDVPPT ANTPTPVRKQ SKRRSNLFTS RKGSDPDKEK KGLESRADSI GSGRAIPIKQ GMLLKRSGKS LNKEWKKKYV TLCDNGVLTY HPSLHDYMQN VHGKEIDLLR TTVKVPGKRP PRATSACAPI SSPKTNGLSK DMSSLHISPN SGNVTSASGS QMASGISLVS FNSRPDGMHQ RSYSVSSADQ WSEATVIANS AISSDTGLGD SVCSSPSISS TTSPKLDPPP SPHANRKKHR RKKSTSNFKA DGLSGTAEEQ EENFEFIIVS LTGQTWHFEA TTYEERDAWV QAIESQILAS LQSCESSKNK SRLTSQSEAM ALQSIRNMRG NSHCVDCETQ NPNWASLNLG ALMCIECSGI HRNLGTHLSR VRSLDLDDWP VELIKVMSSI GNELANSVWE ESSQGRTKPS VDSTREEKER WIRAKYEQKL FLAPLPCTEL SLGQHLLRAT ADEDLRTAIL LLAHGSRDEV NETCGEGDGR TALHLACRKG NVVLAQLLIW YGVDVTARDA HGNTALAYAR QASSQECIDV LLQYGCPDER FVLMATPNLS RRNNNRNNSS GRVPTII
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