About E3 ubiquitin-protein ligase TRIM35
E3 ubiquitin-protein ligase TRIM35 (TRIM35) is a protein
from Homo sapiens identified by UniProt accession
Q9UPQ4, 493 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRIM35 |
|---|
| UniProt accession | Q9UPQ4 |
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| Gene | TRIM35 |
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| Organism | Homo sapiens |
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| Length | 493 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (42)
Diseases linked to this target (Open Targets).
- chronotype measurement · score 0.26
- monocyte count · score 0.11
- Alzheimer disease · score 0.11
- hepatocellular carcinoma · score 0.10
- Takayasu arteritis · score 0.10
- leukocyte count · score 0.10
- myeloid white cell count · score 0.09
- waist circumference · score 0.09
- family history of Alzheimer’s disease · score 0.08
- diffuse large B-cell lymphoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UPQ4-F1 | alphafold | PREDICTED | 88.28 | — |
Amino-acid sequence (493 residues)
MERSPDVSPG PSRSFKEELL CAVCYDPFRD AVTLRCGHNF CRGCVSRCWE VQVSPTCPVC KDRASPADLR TNHTLNNLVE KLLREEAEGA RWTSYRFSRV CRLHRGQLSL FCLEDKELLC CSCQADPRHQ GHRVQPVKDT AHDFRAKCRN MEHALREKAK AFWAMRRSYE AIAKHNQVEA AWLEGRIRQE FDKLREFLRV EEQAILDAMA EETRQKQLLA DEKMKQLTEE TEVLAHEIER LQMEMKEDDV SFLMKHKSRK RRLFCTMEPE PVQPGMLIDV CKYLGSLQYR VWKKMLASVE SVPFSFDPNT AAGWLSVSDD LTSVTNHGYR VQVENPERFS SAPCLLGSRV FSQGSHAWEV ALGGLQSWRV GVVRVRQDSG AEGHSHSCYH DTRSGFWYVC RTQGVEGDHC VTSDPATSPL VLAIPRRLRV ELECEEGELS FYDAERHCHL YTFHARFGEV RPYFYLGGAR GAGPPEPLRI CPLHISVKEE LDG
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