E3 ubiquitin-protein ligase PDZRN3 (PDZRN3)

About E3 ubiquitin-protein ligase PDZRN3

E3 ubiquitin-protein ligase PDZRN3 (PDZRN3) is a protein from Homo sapiens identified by UniProt accession Q9UPQ7, 1066 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase PDZRN3
UniProt accession	Q9UPQ7
Gene	PDZRN3
Organism	Homo sapiens
Length	1066 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (70)

Diseases linked to this target (Open Targets).

FEV/FVC ratio · score 0.43
PR interval · score 0.42
left ventricular structural measurement · score 0.39
cutaneous mastocytosis · score 0.36
Short stature · score 0.32
peak expiratory flow · score 0.32
BMI-adjusted neck circumference · score 0.31
Mastocytosis · score 0.29
irritable bowel syndrome · score 0.29
systemic mastocytosis · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UPQ7-F1	alphafold	PREDICTED	63.09	—

Amino-acid sequence (1066 residues)

MGFELDRFDG DVDPDLKCAL CHKVLEDPLT TPCGHVFCAG CVLPWVVQEG SCPARCRGRL SAKELNHVLP LKRLILKLDI KCAYATRGCG RVVKLQQLPE HLERCDFAPA RCRHAGCGQV LLRRDVEAHM RDACDARPVG RCQEGCGLPL THGEQRAGGH CCARALRAHN GALQARLGAL HKALKKEALR AGKREKSLVA QLAAAQLELQ MTALRYQKKF TEYSARLDSL SRCVAAPPGG KGEETKSLTL VLHRDSGSLG FNIIGGRPSV DNHDGSSSEG IFVSKIVDSG PAAKEGGLQI HDRIIEVNGR DLSRATHDQA VEAFKTAKEP IVVQVLRRTP RTKMFTPPSE SQLVDTGTQT DITFEHIMAL TKMSSPSPPV LDPYLLPEEH PSAHEYYDPN DYIGDIHQEM DREELELEEV DLYRMNSQDK LGLTVCYRTD DEDDIGIYIS EIDPNSIAAK DGRIREGDRI IQINGIEVQN REEAVALLTS EENKNFSLLI ARPELQLDEG WMDDDRNDFL DDLHMDMLEE QHHQAMQFTA SVLQQKKHDE DGGTTDTATI LSNQHEKDSG VGRTDESTRN DESSEQENNG DDATASSNPL AGQRKLTCSQ DTLGSGDLPF SNESFISADC TDADYLGIPV DECERFRELL ELKCQVKSAT PYGLYYPSGP LDAGKSDPES VDKELELLNE ELRSIELECL SIVRAHKMQQ LKEQYRESWM LHNSGFRNYN TSIDVRRHEL SDITELPEKS DKDSSSAYNT GESCRSTPLT LEISPDNSLR RAAEGISCPS SEGAVGTTEA YGPASKNLLS ITEDPEVGTP TYSPSLKELD PNQPLESKER RASDGSRSPT PSQKLGSAYL PSYHHSPYKH AHIPAHAQHY QSYMQLIQQK SAVEYAQSQM SLVSMCKDLS SPTPSEPRME WKVKIRSDGT RYITKRPVRD RLLRERALKI REERSGMTTD DDAVSEMKMG RYWSKEERKQ HLVKAKEQRR RREFMMQSRL DCLKEQQAAD DRKEMNILEL SHKKMMKKRN KKIFDNWMTI QELLTHGTKS PDGTRVYNSF LSVTTV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards