About Dolichol kinase
Dolichol kinase (DOLK) is a protein
from Homo sapiens identified by UniProt accession
Q9UPQ8, 538 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | Dolichol kinase |
|---|
| UniProt accession | Q9UPQ8 |
|---|
| Gene | DOLK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 538 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (43)
Diseases linked to this target (Open Targets).
- DK1-congenital disorder of glycosylation · score 0.79
- congenital disorder of glycosylation · score 0.53
- Abnormality of the cardiovascular system · score 0.51
- SRD5A3-congenital disorder of glycosylation · score 0.46
- familial isolated dilated cardiomyopathy · score 0.37
- congenital disorder of glycosylation type I · score 0.37
- dilated cardiomyopathy · score 0.12
- urinary metabolite measurement · score 0.10
- major depressive disorder · score 0.05
- chronotype measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UPQ8-F1 | alphafold | PREDICTED | 90.08 | — |
Amino-acid sequence (538 residues)
MTRECPSPAP GPGAPLSGSV LAEAAVVFAV VLSIHATVWD RYSWCAVALA VQAFYVQYKW DRLLQQGSAV FQFRMSANSG LLPASMVMPL LGLVMKERCQ TAGNPFFERF GIVVAATGMA VALFSSVLAL GITRPVPTNT CVILGLAGGV IIYIMKHSLS VGEVIEVLEV LLIFVYLNMI LLYLLPRCFT PGEALLVLGG ISFVLNQLIK RSLTLVESQG DPVDFFLLVV VVGMVLMGIF FSTLFVFMDS GTWASSIFFH LMTCVLSLGV VLPWLHRLIR RNPLLWLLQF LFQTDTRIYL LAYWSLLATL ACLVVLYQNA KRSSSESKKH QAPTIARKYF HLIVVATYIP GIIFDRPLLY VAATVCLAVF IFLEYVRYFR IKPLGHTLRS FLSLFLDERD SGPLILTHIY LLLGMSLPIW LIPRPCTQKG SLGGARALVP YAGVLAVGVG DTVASIFGST MGEIRWPGTK KTFEGTMTSI FAQIISVALI LIFDSGVDLN YSYAWILGSI STVSLLEAYT TQIDNLLLPL YLLILLMA
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