About Trinucleotide repeat-containing gene 6B protein
Trinucleotide repeat-containing gene 6B protein (TNRC6B) is a protein
from Homo sapiens identified by UniProt accession
Q9UPQ9, 1833 residues long.
MolForge cross-references it against 0 known binders and
113 disease associations.
Target properties
| Protein name | Trinucleotide repeat-containing gene 6B protein |
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| UniProt accession | Q9UPQ9 |
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| Gene | TNRC6B |
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| Organism | Homo sapiens |
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| Length | 1833 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (113)
Diseases linked to this target (Open Targets).
- global developmental delay with speech and behavioral abnormalities · score 0.64
- genetic disorder · score 0.52
- complex neurodevelopmental disorder · score 0.46
- grip strength measurement · score 0.46
- autism spectrum disorder · score 0.42
- Global developmental delay · score 0.41
- Autistic behavior · score 0.41
- Neurodevelopmental disorder · score 0.40
- Intellectual disability · score 0.37
- neurodevelopmental disorder with dysmorphic facies and distal limb anomalies · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UPQ9-F1 | alphafold | PREDICTED | 39.14 | — |
Amino-acid sequence (1833 residues)
MREKEQEREE QLMEDKKRKK EDKKKKEATQ KVTEQKTKVP EVTKPSLSQP TAASPIGSSP SPPVNGGNNA KRVAVPNGQP PSAARYMPRE VPPRFRCQQD HKVLLKRGQP PPPSCMLLGG GAGPPPCTAP GANPNNAQVT GALLQSESGT APDSTLGGAA ASNYANSTWG SGASSNNGTS PNPIHIWDKV IVDGSDMEEW PCIASKDTES SSENTTDNNS ASNPGSEKST LPGSTTSNKG KGSQCQSASS GNECNLGVWK SDPKAKSVQS SNSTTENNNG LGNWRNVSGQ DRIGPGSGFS NFNPNSNPSA WPALVQEGTS RKGALETDNS NSSAQVSTVG QTSREQQSKM ENAGVNFVVS GREQAQIHNT DGPKNGNTNS LNLSSPNPME NKGMPFGMGL GNTSRSTDAP SQSTGDRKTG SVGSWGAARG PSGTDTVSGQ SNSGNNGNNG KEREDSWKGA SVQKSTGSKN DSWDNNNRST GGSWNFGPQD SNDNKWGEGN KMTSGVSQGE WKQPTGSDEL KIGEWSGPNQ PNSSTGAWDN QKGHPLPENQ GNAQAPCWGR SSSSTGSEVG GQSTGSNHKA GSSDSHNSGR RSYRPTHPDC QAVLQTLLSR TDLDPRVLSN TGWGQTQIKQ DTVWDIEEVP RPEGKSDKGT EGWESAATQT KNSGGWGDAP SQSNQMKSGW GELSASTEWK DPKNTGGWND YKNNNSSNWG GGRPDEKTPS SWNENPSKDQ GWGGGRQPNQ GWSSGKNGWG EEVDQTKNSN WESSASKPVS GWGEGGQNEI GTWGNGGNAS LASKGGWEDC KRSPAWNETG RQPNSWNKQH QQQQPPQQPP PPQPEASGSW GGPPPPPPGN VRPSNSSWSS GPQPATPKDE EPSGWEEPSP QSISRKMDID DGTSAWGDPN SYNYKNVNLW DKNSQGGPAP REPNLPTPMT SKSASVWSKS TPPAPDNGTS AWGEPNESSP GWGEMDDTGA STTGWGNTPA NAPNAMKPNS KSMQDGWGES DGPVTGARHP SWEEEEDGGV WNTTGSQGSA SSHNSASWGQ GGKKQMKCSL KGGNNDSWMN PLAKQFSNMG LLSQTEDNPS SKMDLSVGSL SDKKFDVDKR AMNLGDFNDI MRKDRSGFRP PNSKDMGTTD SGPYFEKLTL PFSNQDGCLG DEAPCSPFSP SPSYKLSPSG STLPNVSLGA IGTGLNPQNF AARQGGSHGL FGNSTAQSRG LHTPVQPLNS SPSLRAQVPP QFISPQVSAS MLKQFPNSGL SPGLFNVGPQ LSPQQIAMLS QLPQIPQFQL ACQLLLQQQQ QQQLLQNQRK ISQAVRQQQE QQLARMVSAL QQQQQQQQRQ PGMKHSPSHP VGPKPHLDNM VPNALNVGLP DLQTKGPIPG YGSGFSSGGM DYGMVGGKEA GTESRFKQWT SMMEGLPSVA TQEANMHKNG AIVAPGKTRG GSPYNQFDII PGDTLGGHTG PAGDSWLPAK SPPTNKIGSK SSNASWPPEF QPGVPWKGIQ NIDPESDPYV TPGSVLGGTA TSPIVDTDHQ LLRDNTTGSN SSLNTSLPSP GAWPYSASDN SFTNVHSTSA KFPDYKSTWS PDPIGHNPTH LSNKMWKNHI SSRNTTPLPR PPPGLTNPKP SSPWSSTAPR SVRGWGTQDS RLASASTWSD GGSVRPSYWL VLHNLTPQID GSTLRTICMQ HGPLLTFHLN LTQGTALIRY STKQEAAKAQ TALHMCVLGN TTILAEFATD DEVSRFLAQA QPPTPAATPS APAAGWQSLE TGQNQSDPVG PALNLFGGST GLGQWSSSAG GSSGADLAGA SLWGPPNYSS SLWGVPTVED PHRMGSPAPL LPGDLLGGGS DSI
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