About Nonsense-mediated mRNA decay factor SMG5
Nonsense-mediated mRNA decay factor SMG5 (SMG5) is a protein
from Homo sapiens identified by UniProt accession
Q9UPR3, 1016 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | Nonsense-mediated mRNA decay factor SMG5 |
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| UniProt accession | Q9UPR3 |
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| Gene | SMG5 |
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| Organism | Homo sapiens |
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| Length | 1016 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (104)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- endometrial cancer · score 0.23
- basophil count · score 0.18
- triglyceride measurement · score 0.14
- monocyte count · score 0.14
- serum albumin measurement · score 0.14
- Red cell distribution width · score 0.13
- mean corpuscular hemoglobin concentration · score 0.12
- HbA1c measurement · score 0.11
- basophil percentage of leukocytes · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UPR3-F1 | alphafold | PREDICTED | 72.87 | — |
Amino-acid sequence (1016 residues)
MSQGPPTGES SEPEAKVLHT KRLYRAVVEA VHRLDLILCN KTAYQEVFKP ENISLRNKLR ELCVKLMFLH PVDYGRKAEE LLWRKVYYEV IQLIKTNKKH IHSRSTLECA YRTHLVAGIG FYQHLLLYIQ SHYQLELQCC IDWTHVTDPL IGCKKPVSAS GKEMDWAQMA CHRCLVYLGD LSRYQNELAG VDTELLAERF YYQALSVAPQ IGMPFNQLGT LAGSKYYNVE AMYCYLRCIQ SEVSFEGAYG NLKRLYDKAA KMYHQLKKCE TRKLSPGKKR CKDIKRLLVN FMYLQSLLQP KSSSVDSELT SLCQSVLEDF NLCLFYLPSS PNLSLASEDE EEYESGYAFL PDLLIFQMVI ICLMCVHSLE RAGSKQYSAA IAFTLALFSH LVNHVNIRLQ AELEEGENPV PAFQSDGTDE PESKEPVEKE EEPDPEPPPV TPQVGEGRKS RKFSRLSCLR RRRHPPKVGD DSDLSEGFES DSSHDSARAS EGSDSGSDKS LEGGGTAFDA ETDSEMNSQE SRSDLEDMEE EEGTRSPTLE PPRGRSEAPD SLNGPLGPSE ASIASNLQAM STQMFQTKRC FRLAPTFSNL LLQPTTNPHT SASHRPCVNG DVDKPSEPAS EEGSESEGSE SSGRSCRNER SIQEKLQVLM AEGLLPAVKV FLDWLRTNPD LIIVCAQSSQ SLWNRLSVLL NLLPAAGELQ ESGLALCPEV QDLLEGCELP DLPSSLLLPE DMALRNLPPL RAAHRRFNFD TDRPLLSTLE ESVVRICCIR SFGHFIARLQ GSILQFNPEV GIFVSIAQSE QESLLQQAQA QFRMAQEEAR RNRLMRDMAQ LRLQLEVSQL EGSLQQPKAQ SAMSPYLVPD TQALCHHLPV IRQLATSGRF IVIIPRTVID GLDLLKKEHP GARDGIRYLE AEFKKGNRYI RCQKEVGKSF ERHKLKRQDA DAWTLYKILD SCKQLTLAQG AGEEDPSGMV TIITGLPLDN PSVLSGPMQA ALQAAAHASV DIKNVLDFYK QWKEIG
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