About Zinc finger RNA-binding protein 2
Zinc finger RNA-binding protein 2 (ZFR2) is a protein
from Homo sapiens identified by UniProt accession
Q9UPR6, 939 residues long.
MolForge cross-references it against 0 known binders and
7 disease associations.
Target properties
| Protein name | Zinc finger RNA-binding protein 2 |
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| UniProt accession | Q9UPR6 |
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| Gene | ZFR2 |
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| Organism | Homo sapiens |
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| Length | 939 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (7)
Diseases linked to this target (Open Targets).
- primary ovarian insufficiency · score 0.12
- energy expenditure · score 0.11
- lymphocyte count · score 0.04
- vulvar intraepithelial neoplasia · score 0.01
- Obesity · score 0.01
- neoplasm · score 0.00
- prostate carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UPR6-F1 | alphafold | PREDICTED | 63.69 | — |
Amino-acid sequence (939 residues)
MATSQYFDFA QGGGPQYSAQ PPTLPLPTVG ASYTAQPTPG MDPAVNPAFP PAAPAGYGGY QPHSGQDFAY GSRPQEPVPT ATTMATYQDS YSYGQSAAAR SYEDRPYFQS AALQSGRMTA ADSGQPGTQE ACGQPSPHGS HSHAQPPQQA PIVESGQPAS TLSSGYTYPT ATGVQPESSA SIVTSYPPPS YNPTCTAYTA PSYPNYDASV YSAASPFYPP AQPPPPPGPP QQLPPPPAPA GSGSSPRADS KPPLPSKLPR PKAGPRQLQL HYCDICKISC AGPQTYREHL GGQKHRKKEA AQKTGVQPNG SPRGVQAQLH CDLCAVSCTG ADAYAAHIRG SKHQKVFKLH AKLGKPIPTL EPALATESPP GAEAKPTSPT GPSVCASSRP ALAKRPVASK ALCEGPPEPQ AAGCRPQWGK PAQPKLEGPG APTQGGSKEA PAGCSDAQPV GPEYVEEVFS DEGRVLRFHC KLCECSFNDL NAKDLHVRGR RHRLQYRKKV NPDLPIATEP SSRARKVLEE RMRKQRHLAE ERLEQLRRWH AERRRLEEEP PQDVPPHAPP DWAQPLLMGR PESPASAPLQ PGRRPASSDD RHVMCKHATI YPTEQELLAV QRAVSHAERA LKLVSDTLAE EDRGRREEEG DKRSSVAPQT RVLKGVMRVG ILAKGLLLRG DRNVRLALLC SEKPTHSLLR RIAQQLPRQL QMVTEDEYEV SSDPEANIVI SSCEEPRMQV TISVTSPLMR EDPSTDPGVE EPQADAGDVL SPKKCLESLA ALRHARWFQA RASGLQPCVI VIRVLRDLCR RVPTWGALPA WAMELLVEKA VSSAAGPLGP GDAVRRVLEC VATGTLLTDG PGLQDPCERD QTDALEPMTL QEREDVTASA QHALRMLAFR QTHKVLGMDL LPPRHRLGAR FRKRQRGPGE GEEGAGEKKR GRRGGEGLV
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