About Ankyrin repeat domain-containing protein 26
Ankyrin repeat domain-containing protein 26 (ANKRD26) is a protein
from Homo sapiens identified by UniProt accession
Q9UPS8, 1710 residues long.
MolForge cross-references it against 0 known binders and
125 disease associations.
Target properties
| Protein name | Ankyrin repeat domain-containing protein 26 |
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| UniProt accession | Q9UPS8 |
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| Gene | ANKRD26 |
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| Organism | Homo sapiens |
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| Length | 1710 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (125)
Diseases linked to this target (Open Targets).
- thrombocytopenia 2 · score 0.78
- Thrombocytopenia · score 0.53
- acute myeloid leukemia · score 0.37
- autosomal thrombocytopenia with normal platelets · score 0.37
- hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1 · score 0.37
- inherited bleeding disorder, platelet-type · score 0.34
- erythrocyte count · score 0.30
- body mass index · score 0.27
- platelet count · score 0.22
- body weight · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UPS8-F1 | alphafold | PREDICTED | 62.30 | — |
Amino-acid sequence (1710 residues)
MKKIFSKKGE SPLGSFARRQ RSSAGGGGEP GEGAYSQPGY HVRDRDLGKI HKAASAGNVA KVQQILLLRK NGLNDRDKMN RTALHLACAN GHPEVVTLLV DRKCQLNVCD NENRTALMKA VQCQEEKCAT ILLEHGADPN LADVHGNTAL HYAVYNEDIS VATKLLLYDA NIEAKNKDDL TPLLLAVSGK KQQMVEFLIK KKANVNAVDK LESSHQLISE YKEERIPKHS SQNSNSVDES SEDSLSRLSG KPGVDDSWPT SDDEDLNFDT KNVPKPSLAK LMTASQQSRK NLEATYGTVR TGNRTLFEDR DSDSQDEVVV ESLPTTSIKV QCFSHPTYQS PDLLPKPSHK SLANPGLMKE EPTKPGIAKK ENGIDIIESA PLEQTNNDNL TYVDEVHKNN RSDMMSALGL GQEEDIESPW DSESISENFP QKYVDPLAGA ADGKEKNIGN EQAEDVFYIP SCMSGSRNFK MAKLEDTRNV GMPVAHMESP ERYLHLKPTI EMKDSVPNKA GGMKDVQTSK AAEHDLEVAS EEEQEREGSE NNQPQVEEER KKHRNNEMEV SANIHDGATD DAEDDDDDDG LIQKRKSGET DHQQFPRKEN KEYASSGPAL QMKEVKSTEK EKRTSKESVN SPVFGKASLL TGGLLQVDDD SSLSEIDEDE GRPTKKTSNE KNKVKNQIQS MDDVDDLTQS SETASEDCEL PHSSYKNFML LIEQLGMECK DSVSLLKIQD AALSCERLLE LKKNHCELLT VKIKKMEDKV NVLQRELSET KEIKSQLEHQ KVEWERELCS LRFSLNQEEE KRRNADTLYE KIREQLRRKE EQYRKEVEVK QQLELSLQTL EMELRTVKSN LNQVVQERND AQRQLSREQN ARMLQDGILT NHLSKQKEIE MAQKKMNSEN SHSHEEEKDL SHKNSMLQEE IAMLRLEIDT IKNQNQEKEK KCFEDLKIVK EKNEDLQKTI KQNEETLTQT ISQYNGRLSV LTAENAMLNS KLENEKQSKE RLEAEVESYH SRLAAAIHDR DQSETSKREL ELAFQRARDE CSRLQDKMNF DVSNLKDNNE ILSQQLFKTE SKLNSLEIEF HHTRDALREK TLGLERVQKD LSQTQCQMKE MEQKYQNEQV KVNKYIGKQE SVEERLSQLQ SENMLLRQQL DDAHNKADNK EKTVINIQDQ FHAIVQKLQA ESEKQSLLLE ERNKELISEC NHLKERQYQY ENEKAEREVV VRQLQQELAD TLKKQSMSEA SLEVTSRYRI NLEDETQDLK KKLGQIRNQL QEAQDRHTEA VRCAEKMQDH KQKLEKDNAK LKVTVKKQMD KIEELQKNLL NANLSEDEKE QLKKLMELKQ SLECNLDQEM KKNVELEREI TGFKNLLKMT RKKLNEYENG EFSFHGDLKT SQFEMDIQIN KLKHKIDDLT AELETAGSKC LHLDTKNQIL QEELLSMKTV QKKCEKLQKN KKKLEQEVIN LRSHIERNMV ELGQVKQYKQ EIEERARQEI AEKLKEVNLF LQAQAASQEN LEQFRENNFA SMKSQMELRI KDLESELSKI KTSQEDFNKT ELEKYKQLYL EELKVRKSLS SKLTKTNERL AEVNTKLLVE KQQSRSLFTT LTTRPVMEPP CVGNLNNSLD LNRKLIPREN LVISTSNPRA SNNSMENYLS KMQQELEKNI TRELKEAAAE LESGSIASPL GSTDESNLNQ DLVWKASREY VQVLKKNYMI
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