About Forkhead box protein J3
Forkhead box protein J3 (FOXJ3) is a protein
from Homo sapiens identified by UniProt accession
Q9UPW0, 622 residues long.
MolForge cross-references it against 0 known binders and
122 disease associations.
Target properties
| Protein name | Forkhead box protein J3 |
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| UniProt accession | Q9UPW0 |
|---|
| Gene | FOXJ3 |
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| Organism | Homo sapiens |
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| Length | 622 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (122)
Diseases linked to this target (Open Targets).
- age at menarche · score 0.17
- systolic blood pressure · score 0.16
- body fat percentage · score 0.09
- colorectal carcinoma · score 0.07
- Familial short QT syndrome · score 0.07
- Romano-Ward syndrome · score 0.06
- familial atrial fibrillation · score 0.06
- essential tremor · score 0.06
- Arrhythmogenic right ventricular dysplasia · score 0.06
- Brugada syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UPW0-F1 | alphafold | PREDICTED | 53.58 | — |
Amino-acid sequence (622 residues)
MGLYGQACPS VTSLRMTSEL ESSLTSMDWL PQLTMRAAIQ KSDATQNAHG TGISKKNALL DPNTTLDQEE VQQHKDGKPP YSYASLITFA INSSPKKKMT LSEIYQWICD NFPYYREAGS GWKNSIRHNL SLNKCFLKVP RSKDDPGKGS YWAIDTNPKE DVLPTRPKKR ARSVERASTP YSIDSDSLGM ECIISGSASP TLAINTVTNK VTLYNTDQDG SDSPRSSLNN SLSDQSLASV NLNSVGSVHS YTPVTSHPES VSQSLTPQQQ PQYNLPERDK QLLFSEYNFE DLSASFRSLY KSVFEQSLSQ QGLMNIPSES SQQSHTSCTY QHSPSSTVST HPHSNQSSLS NSHGSGLNTT GSNSVAQVSL SHPQMHTQPS PHPPHRPHGL PQHPQRSPHP APHPQQHSQL QSPHPQHPSP HQHIQHHPNH QHQTLTHQAP PPPQQVSCNS GVSNDWYATL DMLKESCRIA SSVNWSDVDL SQFQGLMESM RQADLKNWSL DQVQFADLCS SLNQFFTQTG LIHSQSNVQQ NVCHGAMHPT KPSQHIGTGN LYIDSRQNLP PSVMPPPGYP HIPQALSTPG TTMAGHHRAM NQQHMMPSQA FQMRRSLPPD DIQDDFDWDS IV
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