About Major intrinsically disordered Notch2-binding receptor 1
Major intrinsically disordered Notch2-binding receptor 1 (MINAR1) is a protein
from Homo sapiens identified by UniProt accession
Q9UPX6, 916 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Major intrinsically disordered Notch2-binding receptor 1 |
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| UniProt accession | Q9UPX6 |
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| Gene | MINAR1 |
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| Organism | Homo sapiens |
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| Length | 916 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- testosterone measurement · score 0.44
- PHF-tau measurement · score 0.22
- blood protein measurement · score 0.09
- neoplasm · score 0.07
- breast carcinoma · score 0.03
- refractive error measurement · score 0.02
- neurofibrillary tangles measurement · score 0.02
- cancer · score 0.02
- Intellectual disability · score 0.01
- nervous system disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UPX6-F1 | alphafold | PREDICTED | 49.64 | — |
Amino-acid sequence (916 residues)
METSQETSLF LVKILEELDS KQNTVSYQDL CKSLCARFDL SQLAKLRSVL FYTACLDPNF PATLFKDKMK CTVNNQQSKK IMVAADIVTI FNLIQMNGGA AKEKLPTGRQ KVRKKEASFE SCRSDTEICN AAECEPLNCE LSERSFSRGY PIRQSSKCRK MDCKDCPQFV PASEPNFLLG VSKEVKNRAA SLDRLQALAP YSVTSPQPCE MQRTYFPMNI ENESISDQDS LPINQSIKET FISNEEPFVV QSCVQKRNIF KEDFHNLMAV SPSLVGPISK AENEHREPQS RKEPHKPPFF NHSFEMPYNS QYLNPVYSPV PDKRRAKHES LDDLQASTYF GPTPVMGTQE ARRCLGKPNK QTPWPAKSWS LNTEEVPDFE RSFFNRNPSE EKLHYPNASS QTPNFPAPER RPTYLVPKDQ QPILPIAYAA KQNGLKSKEI SSPVDLEKHE PVKKFKDKSI NCTSGQLSSD TSSVGTQTEH VLEPKKCRDL CTSGQGKYSD RHTMKHSDDD SEIVSDDISD IFRFLDDMSI SGSTGVIQSS CYNSTGSLSQ LHKSDCDSSP EHNLTKIANG VPNSKGDKGN RPENTHHSEE ELKTSVCKLV LRIGEIERKL ESLSGVRDEI SQVLGKLNKL DQKMQQPEKV SVQIDLNSLT SEGPSDDSAS PRMFHAHSGS HGPKLENNPD WCCSDASGSN SESLRVKALK KSLFTRPSSR SLTEENSATE SKIASISNSP RDWRTITYTN RVGLNEEEIK DTGPGDNKDW HRKSKEADRQ YDIPPQHRLP KQPKDGFLVE QVFSPHPYPA SLKAHMKSNP LYTDMRLTEL AEVKRGQPSW TIEEYARNAG DKGKLTALDL QTQESLNPNN LEYWMEDIYT PGYDSLLKRK EAEFRRAKVC KIAALIAAAA CTVILVIVVP ICTMKS
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