About Serine/threonine-protein kinase ICK
Serine/threonine-protein kinase ICK (CILK1) is a protein
from Homo sapiens identified by UniProt accession
Q9UPZ9, 632 residues long.
MolForge cross-references it against 0 known binders and
328 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase ICK |
|---|
| UniProt accession | Q9UPZ9 |
|---|
| Gene | CILK1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 632 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (328)
Diseases linked to this target (Open Targets).
- endocrine-cerebro-osteodysplasia syndrome · score 0.57
- juvenile myoclonic epilepsy · score 0.38
- short rib-polydactyly syndrome · score 0.26
- smoking status measurement · score 0.24
- attention deficit hyperactivity disorder · score 0.23
- antisocial behaviour measurement · score 0.23
- substance abuse · score 0.23
- smoking behaviour measurement · score 0.20
- age at first sexual intercourse measurement · score 0.15
- coloboma · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UPZ9-F1 | alphafold | PREDICTED | 60.77 | — |
Amino-acid sequence (632 residues)
MNRYTTIRQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE VKSLKKLNHA NVVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES AIRNIMYQIL QGLAFIHKHG FFHRDLKPEN LLCMGPELVK IADFGLAREI RSKPPYTDYV STRWYRAPEV LLRSTNYSSP IDVWAVGCIM AEVYTLRPLF PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFRWPQ CVPNNLKTLI PNASSEAVQL LRDMLQWDPK KRPTASQALR YPYFQVGHPL GSTTQNLQDS EKPQKGILEK AGPPPYIKPV PPAQPPAKPH TRISSRQHQA SQPPLHLTYP YKAEVSRTDH PSHLQEDKPS PLLFPSLHNK HPQSKITAGL EHKNGEIKPK SRRRWGLISR STKDSDDWAD LDDLDFSPSL SRIDLKNKKR QSDDTLCRFE SVLDLKPSEP VGTGNSAPTQ TSYQRRDTPT LRSAAKQHYL KHSRYLPGIS IRNGILSNPG KEFIPPNPWS SSGLSGKSSG TMSVISKVNS VGSSSTSSSG LTGNYVPSFL KKEIGSAMQR VHLAPIPDPS PGYSSLKAMR PHPGRPFFHT QPRSTPGLIP RPPAAQPVHG RTDWASKYAS RR
Explore Serine/threonine-protein kinase ICK with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets