About C-Jun-amino-terminal kinase-interacting protein 1
C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1) is a protein
from Homo sapiens identified by UniProt accession
Q9UQF2, 711 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | C-Jun-amino-terminal kinase-interacting protein 1 |
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| UniProt accession | Q9UQF2 |
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| Gene | MAPK8IP1 |
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| Organism | Homo sapiens |
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| Length | 711 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (81)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.41
- neurodegenerative disease · score 0.39
- high density lipoprotein cholesterol measurement · score 0.33
- protein measurement · score 0.27
- fasting blood glucose measurement · score 0.12
- glucose measurement · score 0.11
- traffic air pollution measurement · score 0.11
- Alzheimer disease · score 0.10
- sex hormone-binding globulin measurement · score 0.09
- gonorrhea · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UQF2-F1 | alphafold | PREDICTED | 54.03 | — |
Amino-acid sequence (711 residues)
MAERESGGLG GGAASPPAAS PFLGLHIASP PNFRLTHDIS LEEFEDEDLS EITDECGISL QCKDTLSLRP PRAGLLSAGG GGAGSRLQAE MLQMDLIDAT GDTPGAEDDE EDDDEERAAR RPGAGPPKAE SGQEPASRGQ GQSQGQSQGP GSGDTYRPKR PTTLNLFPQV PRSQDTLNNN SLGKKHSWQD RVSRSSSPLK TGEQTPPHEH ICLSDELPPQ SGPAPTTDRG TSTDSPCRRS TATQMAPPGG PPAAPPGGRG HSHRDRIHYQ ADVRLEATEE IYLTPVQRPP DAAEPTSAFL PPTESRMSVS SDPDPAAYPS TAGRPHPSIS EEEEGFDCLS SPERAEPPGG GWRGSLGEPP PPPRASLSSD TSALSYDSVK YTLVVDEHAQ LELVSLRPCF GDYSDESDSA TVYDNCASVS SPYESAIGEE YEEAPRPQPP ACLSEDSTPD EPDVHFSKKF LNVFMSGRSR SSSAESFGLF SCIINGEEQE QTHRAIFRFV PRHEDELELE VDDPLLVELQ AEDYWYEAYN MRTGARGVFP AYYAIEVTKE PEHMAALAKN SDWVDQFRVK FLGSVQVPYH KGNDVLCAAM QKIATTRRLT VHFNPPSSCV LEISVRGVKI GVKADDSQEA KGNKCSHFFQ LKNISFCGYH PKNNKYFGFI TKHPADHRFA CHVFVSEDST KALAESVGRA FQQFYKQFVE YTCPTEDIYL E
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