Acetylcholinesterase collagenic tail peptide (COLQ)

About Acetylcholinesterase collagenic tail peptide

Acetylcholinesterase collagenic tail peptide (COLQ) is a protein from Homo sapiens identified by UniProt accession Q9Y215, 455 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	Acetylcholinesterase collagenic tail peptide
UniProt accession	Q9Y215
Gene	COLQ
Organism	Homo sapiens
Length	455 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

Congenital myasthenic syndromes · score 0.80
Synaptic congenital myasthenic syndromes · score 0.78
congenital myasthenic syndrome · score 0.53
synaptic congenital myasthenic syndrome · score 0.51
Abnormality of the musculature · score 0.49
blood protein measurement · score 0.30
diverticular disease · score 0.27
birth weight · score 0.26
diverticulitis · score 0.25
genetic disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y215-F1	alphafold	PREDICTED	54.46	—

Amino-acid sequence (455 residues)

MVVLNPMTLG IYLQLFFLSI VSQPTFINSV LPISAALPSL DQKKRGGHKA CCLLTPPPPP LFPPPFFRGG RSPLLSPDMK NLMLELETSQ SPCMQGSLGS PGPPGPQGPP GLPGKTGPKG EKGELGRPGR KGRPGPPGVP GMPGPIGWPG PEGPRGEKGD LGMMGLPGSR GPMGSKGYPG SRGEKGSRGE KGDLGPKGEK GFPGFPGMLG QKGEMGPKGE PGIAGHRGPT GRPGKRGKQG QKGDSGVMGP PGKPGPSGQP GRPGPPGPPP AGQLIMGPKG ERGFPGPPGR CLCGPTMNVN NPSYGESVYG PSSPRVPVIF VVNNQEELER LNTQNAIAFR RDQRSLYFKD SLGWLPIQLT PFYPVDYTAD QHGTCGDGLL QPGEECDDGN SDVGDDCIRC HRAYCGDGHR HEGVEDCDGS DFGYLTCETY LPGSYGDLQC TQYCYIDSTP CRYFT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards