About Phosphatidylinositol-3-phosphate phosphatase MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7 (MTMR7) is a protein
from Homo sapiens identified by UniProt accession
Q9Y216, 660 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Phosphatidylinositol-3-phosphate phosphatase MTMR7 |
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| UniProt accession | Q9Y216 |
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| Gene | MTMR7 |
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| Organism | Homo sapiens |
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| Length | 660 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (24)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- Creutzfeldt Jacob Disease · score 0.27
- total blood protein measurement · score 0.26
- insomnia · score 0.26
- breast adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.11
- neoplasm · score 0.08
- lung carcinoma · score 0.03
- type 2 diabetes mellitus · score 0.03
- cancer · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y216-F1 | alphafold | PREDICTED | 83.60 | — |
Amino-acid sequence (660 residues)
MEHIRTPKVE NVRLVDRVSP KKAALGTLYL TATHVIFVEN SPDPRKETWI LHSQISTIEK QATTATGCPL LIRCKNFQII QLIIPQERDC HDVYISLIRL ARPVKYEELY CFSFNPMLDK EEREQGWVLI DLSEEYTRMG LPNHYWQLSD VNRDYRVCDS YPTELYVPKS ATAHIIVGSS KFRSRRRFPV LSYYYKDNHA SICRSSQPLS GFSARCLEDE QMLQAIRKAN PGSDFVYVVD TRPKLNAMAN RAAGKGYENE DNYSNIKFQF IGIENIHVMR NSLQKMLEVC ELKSPSMSDF LWGLENSGWL RHIKAIMDAG IFIAKAVSEE GASVLVHCSD GWDRTAQVCS VASLLLDPHY RTLKGFMVLI EKDWISFGHK FNHRYGNLDG DPKEISPVID QFIECVWQLM EQFPCAFEFN ERFLIHIQHH IYSCQFGNFL CNSQKERREL KIQERTYSLW AHLWKNRADY LNPLFRADHS QTQGTLHLPT TPCNFMYKFW SGMYNRFEKG MQPRQSVTDY LMAVKEETQQ LEEELEALEE RLEKIQKVQL NCTKVKSKQS EPSKHSGFST SDNSIANTPQ DYSGNMKSFP SRSPSQGDED SALILTQDNL KSSDPDLSAN SDQESGVEDL SCRSPSGGEH APSEDSGKDR DSDEAVFLTA
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