About Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is a protein
from Homo sapiens identified by UniProt accession
Q9Y223, 722 residues long.
MolForge cross-references it against 0 known binders and
268 disease associations.
Target properties
| Protein name | Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase |
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| UniProt accession | Q9Y223 |
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| Gene | GNE |
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| Organism | Homo sapiens |
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| Length | 722 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (268)
Diseases linked to this target (Open Targets).
- GNE myopathy · score 0.84
- sialuria · score 0.82
- Distal myopathy, Nonaka type · score 0.82
- inclusion body myositis · score 0.64
- distal myopathy · score 0.47
- limb-girdle muscular dystrophy · score 0.46
- genetic disorder · score 0.44
- platelet-type bleeding disorder 19 · score 0.37
- hereditary nonpolyposis colon cancer · score 0.34
- Thrombocytopenia · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y223-F1 | alphafold | PREDICTED | 93.11 | — |
Amino-acid sequence (722 residues)
MEKNGNNRKL RVCVATCNRA DYSKLAPIMF GIKTEPEFFE LDVVVLGSHL IDDYGNTYRM IEQDDFDINT RLHTIVRGED EAAMVESVGL ALVKLPDVLN RLKPDIMIVH GDRFDALALA TSAALMNIRI LHIEGGEVSG TIDDSIRHAI TKLAHYHVCC TRSAEQHLIS MCEDHDRILL AGCPSYDKLL SAKNKDYMSI IRMWLGDDVK SKDYIVALQH PVTTDIKHSI KMFELTLDAL ISFNKRTLVL FPNIDAGSKE MVRVMRKKGI EHHPNFRAVK HVPFDQFIQL VAHAGCMIGN SSCGVREVGA FGTPVINLGT RQIGRETGEN VLHVRDADTQ DKILQALHLQ FGKQYPCSKI YGDGNAVPRI LKFLKSIDLQ EPLQKKFCFP PVKENISQDI DHILETLSAL AVDLGGTNLR VAIVSMKGEI VKKYTQFNPK TYEERINLIL QMCVEAAAEA VKLNCRILGV GISTGGRVNP REGIVLHSTK LIQEWNSVDL RTPLSDTLHL PVWVDNDGNC AALAERKFGQ GKGLENFVTL ITGTGIGGGI IHQHELIHGS SFCAAELGHL VVSLDGPDCS CGSHGCIEAY ASGMALQREA KKLHDEDLLL VEGMSVPKDE AVGALHLIQA AKLGNAKAQS ILRTAGTALG LGVVNILHTM NPSLVILSGV LASHYIHIVK DVIRQQALSS VQDVDVVVSD LVDPALLGAA SMVLDYTTRR IY
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