tRNA-splicing ligase complex subunit RTRAF (RTRAF)

About tRNA-splicing ligase complex subunit RTRAF

tRNA-splicing ligase complex subunit RTRAF (RTRAF) is a protein from Homo sapiens identified by UniProt accession Q9Y224, 244 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.

Target properties

Protein name	tRNA-splicing ligase complex subunit RTRAF
UniProt accession	Q9Y224
Gene	RTRAF
Organism	Homo sapiens
Length	244 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (114)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.13
polyp of colon · score 0.11
FEV/FVC ratio · score 0.08
non-small cell lung carcinoma · score 0.08
esophageal squamous cell carcinoma · score 0.07
urinary bladder carcinoma · score 0.07
triglyceride measurement · score 0.06
Young adult-onset Parkinsonism · score 0.06
essential tremor · score 0.06
high density lipoprotein cholesterol measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y224-F1	alphafold	PREDICTED	71.63	—

Amino-acid sequence (244 residues)

MFRRKLTALD YHNPAGFNCK DETEFRNFIV WLEDQKIRHY KIEDRGNLRN IHSSDWPKFF EKYLRDVNCP FKIQDRQEAI DWLLGLAVRL EYGDNAEKYK DLVPDNSKTA DNATKNAEPL INLDVNNPDF KAGVMALANL LQIQRHDDYL VMLKAIRILV QERLTQDAVA KANQTKEGLP VALDKHILGF DTGDAVLNEA AQILRLLHIE ELRELQTKIN EAIVAVQAII ADPKTDHRLG KVGR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards