About Ectonucleoside triphosphate diphosphohydrolase 4
Ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4) is a protein
from Homo sapiens identified by UniProt accession
Q9Y227, 616 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | Ectonucleoside triphosphate diphosphohydrolase 4 |
|---|
| UniProt accession | Q9Y227 |
|---|
| Gene | ENTPD4 |
|---|
| Organism | Homo sapiens |
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| Length | 616 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (43)
Diseases linked to this target (Open Targets).
- birth weight · score 0.24
- Red cell distribution width · score 0.24
- body height · score 0.24
- thyroid stimulating hormone measurement · score 0.24
- basophil percentage of leukocytes · score 0.21
- reticulocyte count · score 0.17
- mean corpuscular hemoglobin · score 0.08
- mean corpuscular hemoglobin concentration · score 0.07
- lean body mass · score 0.06
- sex hormone-binding globulin measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y227-F1 | alphafold | PREDICTED | 87.27 | — |
Amino-acid sequence (616 residues)
MGRIGISCLF PASWHFSISP VGCPRILNTN LRQIMVISVL AAAVSLLYFS VVIIRNKYGR LTRDKKFQRY LARVTDIEAT DTNNPNVNYG IVVDCGSSGS RVFVYCWPRH NGNPHDLLDI RQMRDKNRKP VVMKIKPGIS EFATSPEKVS DYISPLLNFA AEHVPRAKHK ETPLYILCTA GMRILPESQQ KAILEDLLTD IPVHFDFLFS DSHAEVISGK QEGVYAWIGI NFVLGRFEHI EDDDEAVVEV NIPGSESSEA IVRKRTAGIL DMGGVSTQIA YEVPKTVSFA SSQQEEVAKN LLAEFNLGCD VHQTEHVYRV YVATFLGFGG NAARQRYEDR IFANTIQKNR LLGKQTGLTP DMPYLDPCLP LDIKDEIQQN GQTIYLRGTG DFDLCRETIQ PFMNKTNETQ TSLNGVYQPP IHFQNSEFYG FSEFYYCTED VLRMGGDYNA AKFTKAAKDY CATKWSILRE RFDRGLYASH ADLHRLKYQC FKSAWMFEVF HRGFSFPVNY KSLKTALQVY DKEVQWTLGA ILYRTRFLPL RDIQQEAFRA SHTHWRGVSF VYNHYLFSGC FLVVLLAILL YLLRLRRIHR RTPRSSSAAA LWMEEGLPAQ NAPGTL
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