About RuvB-like 2
RuvB-like 2 (RUVBL2) is a protein
from Homo sapiens identified by UniProt accession
Q9Y230, 463 residues long.
MolForge cross-references it against 0 known binders and
201 disease associations.
Target properties
| Protein name | RuvB-like 2 |
|---|
| UniProt accession | Q9Y230 |
|---|
| Gene | RUVBL2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 463 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (201)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- blood protein measurement · score 0.24
- breast adenocarcinoma · score 0.24
- endometrial cancer · score 0.16
- glycogen storage disease due to muscle and heart glycogen synthase deficiency · score 0.12
- testosterone measurement · score 0.11
- hepatocellular carcinoma · score 0.10
- neoplasm · score 0.09
- cancer · score 0.09
- human Chorionic Gonadotropin measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y230-F1 | alphafold | PREDICTED | 84.15 | — |
Amino-acid sequence (463 residues)
MATVTATTKV PEIRDVTRIE RIGAHSHIRG LGLDDALEPR QASQGMVGQL AARRAAGVVL EMIREGKIAG RAVLIAGQPG TGKTAIAMGM AQALGPDTPF TAIAGSEIFS LEMSKTEALT QAFRRSIGVR IKEETEIIEG EVVEIQIDRP ATGTGSKVGK LTLKTTEMET IYDLGTKMIE SLTKDKVQAG DVITIDKATG KISKLGRSFT RARDYDAMGS QTKFVQCPDG ELQKRKEVVH TVSLHEIDVI NSRTQGFLAL FSGDTGEIKS EVREQINAKV AEWREEGKAE IIPGVLFIDE VHMLDIESFS FLNRALESDM APVLIMATNR GITRIRGTSY QSPHGIPIDL LDRLLIVSTT PYSEKDTKQI LRIRCEEEDV EMSEDAYTVL TRIGLETSLR YAIQLITAAS LVCRKRKGTE VQVDDIKRVY SLFLDESRST QYMKEYQDAF LFNELKGETM DTS
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