About C->U-editing enzyme APOBEC-2
C->U-editing enzyme APOBEC-2 (APOBEC2) is a protein
from Homo sapiens identified by UniProt accession
Q9Y235, 224 residues long.
MolForge cross-references it against 0 known binders and
182 disease associations.
Target properties
| Protein name | C->U-editing enzyme APOBEC-2 |
|---|
| UniProt accession | Q9Y235 |
|---|
| Gene | APOBEC2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 224 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (182)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- lymphocyte count · score 0.17
- body height · score 0.16
- body mass index · score 0.16
- type 2 diabetes mellitus · score 0.15
- cutaneous melanoma · score 0.14
- gastric carcinoma · score 0.13
- monocyte count · score 0.09
- myopathy · score 0.08
- esophageal carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y235-F1 | alphafold | PREDICTED | 72.39 | — |
Amino-acid sequence (224 residues)
MAQKEEAAVA TEAASQNGED LENLDDPEKL KELIELPPFE IVTGERLPAN FFKFQFRNVE YSSGRNKTFL CYVVEAQGKG GQVQASRGYL EDEHAAAHAE EAFFNTILPA FDPALRYNVT WYVSSSPCAA CADRIIKTLS KTKNLRLLIL VGRLFMWEEP EIQAALKKLK EAGCKLRIMK PQDFEYVWQN FVEQEEGESK AFQPWEDIQE NFLYYEEKLA DILK
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