Oxidative stress-induced growth inhibitor 2 (OSGIN2)

About Oxidative stress-induced growth inhibitor 2

Oxidative stress-induced growth inhibitor 2 (OSGIN2) is a protein from Homo sapiens identified by UniProt accession Q9Y236, 505 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Oxidative stress-induced growth inhibitor 2
UniProt accession	Q9Y236
Gene	OSGIN2
Organism	Homo sapiens
Length	505 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.38
Crohn's disease · score 0.36
diastolic blood pressure · score 0.26
ulcerative colitis · score 0.17
ankylosing spondylitis · score 0.17
psoriasis · score 0.17
sclerosing cholangitis · score 0.17
inflammatory bowel disease · score 0.09
leprosy · score 0.08
ulcer disease · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y236-F1	alphafold	PREDICTED	87.71	—

Amino-acid sequence (505 residues)

MPLVEETSLL EDSSVTFPVV IIGNGPSGIC LSYMLSGYRP YLSSEAIHPN TILNSKLEEA RHLSIVDQDL EYLSEGLEGR SSNPVAVLFD TLLHPDADFG YDYPSVLHWK LEQHHYIPHV VLGKGPPGGA WHNMEGSMLT ISFGSWMELP GLKFKDWVSS KRRSLKGDRV MPEEIARYYK HYVKVMGLQK NFRENTYITS VSRLYRDQDD DDIQDRDIST KHLQIEKSNF IKRNWEIRGY QRIADGSHVP FCLFAENVAL ATGTLDSPAH LEIEGEDFPF VFHSMPEFGA AINKGKLRGK VDPVLIVGSG LTAADAVLCA YNSNIPVIHV FRRRVTDPSL IFKQLPKKLY PEYHKVYHMM CTQSYSVDSN LLSDYTSFPE HRVLSFKSDM KCVLQSVSGL KKIFKLSAAV VLIGSHPNLS FLKDQGCYLG HKSSQPITCK GNPVEIDTYT YECIKEANLF ALGPLVGDNF VRFLKGGALG VTRCLATRQK KKHLFVERGG GDGIA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards